Segmentation is a fundamental feature of the vertebrate body plan. This metameric
organization is first implemented by somitogenesis in the early embryo, when paired …

Segmentation of the paraxial mesoderm is a major event of vertebrate development that
establishes the metameric patterning of the body axis. This process involves the periodic …

Animals display substantial inter-species variation in the rate of embryonic development
despite a broad conservation of the overall sequence of developmental events. Differences …

Although mechanisms of embryonic development are similar between mice and humans,
the time scale is generally slower in humans. To investigate these interspecies differences in …

Pluripotent stem cells are increasingly used to model different aspects of embryogenesis
and organ formation. Despite recent advances in in vitro induction of major mesodermal …

The segmentation clock is an oscillating genetic network thought to govern the rhythmic and
sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the …

The fibroblast growth factor (Fgf) family of ligands and receptor tyrosine kinases is required
throughout embryonic and postnatal development and also regulates multiple homeostatic …

How signaling dynamics encode information is a central question in biology. During
vertebrate development, dynamic Notch signaling oscillations control segmentation of the …

One of the most striking features of the human vertebral column is its periodic organization
along the anterior-posterior axis. This pattern is established when segments of vertebrates …

Pluripotent stem cells (PSCs) are attractive regenerative therapy tools for skeletal tissues.
However, a deep understanding of skeletal development is required in order to model this …