Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …

Recent data show that B cells and plasma cells located in tumours or in tumour-draining
lymph nodes can have important roles in sha** antitumour immune responses. In tumour …

Tumor progression and the efficacy of immunotherapy are strongly influenced by the
composition and abundance of immune cells in the tumor microenvironment. Due to the …

Abstract Treatment with immune checkpoint blockade (ICB) has revolutionized cancer
therapy. Until now, predictive biomarkers,,,,,,,,–and strategies to augment clinical response …

We introduce the TRUST4 open-source algorithm for reconstruction of immune receptor
repertoires in αβ/γδ T cells and B cells from RNA-sequencing (RNA-seq) data. Compared …

Our understanding of tumor-infiltrating lymphocytes (TILs) is rapidly expanding beyond T cell-
centric perspectives to include B cells and plasma cells, collectively referred to as TIL-Bs. In …

Sequence alterations in microsatellites and an elevated mutational burden are observed in
20% of gastric cancers and associated with clinical response to anti–PD-1 antibodies …

The tumor microenvironment hosts antibody-secreting cells (ASCs) associated with a
favorable prognosis in several types of cancer. Patient-derived antibodies have diagnostic …

The cascade of metastasis in tumor cells, exhibiting organ-specific tendencies, may occur at
numerous phases of the disease and progress under intense evolutionary pressures. Organ …

Tumor cells pose a challenge to the adaptive immune system, and its key cell types, T and B
cells, have frequently been associated with an improved prognosis. The success of immune …