Dual RNA-seq of pathogen and host
AJ Westermann, SA Gorski, J Vogel - Nature Reviews Microbiology, 2012 - nature.com
A comprehensive understanding of host–pathogen interactions requires a knowledge of the
associated gene expression changes in both the pathogen and the host. Traditional, probe …
associated gene expression changes in both the pathogen and the host. Traditional, probe …
Signal Transduction and Regulatory Mechanisms Involved in Control of the σS (RpoS) Subunit of RNA Polymerase
R Hengge-Aronis - Microbiology and molecular biology reviews, 2002 - Am Soc Microbiol
The σS (RpoS) subunit of RNA polymerase is the master regulator of the general stress
response in Escherichia coli and related bacteria. While rapidly growing cells contain very …
response in Escherichia coli and related bacteria. While rapidly growing cells contain very …
Both silver ions and silver nanoparticles facilitate the horizontal transfer of plasmid-mediated antibiotic resistance genes
Antibiotic resistance in bacteria is a growing threat to global human health. Horizontal gene
transfer (HGT) of antibiotic resistance genes (ARGs) is recognized as the primary contributor …
transfer (HGT) of antibiotic resistance genes (ARGs) is recognized as the primary contributor …
Phenotypic variation of Salmonella in host tissues delays eradication by antimicrobial chemotherapy
B Claudi, P Spröte, A Chirkova, N Personnic, J Zankl… - Cell, 2014 - cell.com
Antibiotic therapy often fails to eliminate a fraction of transiently refractory bacteria, causing
relapses and chronic infections. Multiple mechanisms can induce such persisters with high …
relapses and chronic infections. Multiple mechanisms can induce such persisters with high …
Identifying small proteins by ribosome profiling with stalled initiation complexes
Small proteins consisting of 50 or fewer amino acids have been identified as regulators of
larger proteins in bacteria and eukaryotes. Despite the importance of these molecules, the …
larger proteins in bacteria and eukaryotes. Despite the importance of these molecules, the …
Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest
F Hayes - Science, 2003 - science.org
Antibiotic resistance, virulence, and other plasmids in bacteria use toxin-antitoxin gene pairs
to ensure their persistence during host replication. The toxin-antitoxin system eliminates …
to ensure their persistence during host replication. The toxin-antitoxin system eliminates …
A macromolecule reversing antibiotic resistance phenotype and repurposing drugs as potent antibiotics
In order to mitigate antibiotic resistance, a new strategy to increase antibiotic potency and
reverse drug resistance is needed. Herein, the translocation mechanism of an antimicrobial …
reverse drug resistance is needed. Herein, the translocation mechanism of an antimicrobial …
Selfish operons: the evolutionary impact of gene clustering in prokaryotes and eukaryotes
J Lawrence - Current opinion in genetics & development, 1999 - Elsevier
The Selfish Operon Model postulates that the organization of bacterial genes into operons is
beneficial to the constituent genes in that proximity allows horizontal cotransfer of all genes …
beneficial to the constituent genes in that proximity allows horizontal cotransfer of all genes …
Adaptation of Akkermansia muciniphila to the oxic-anoxic interface of the mucus layer
Akkermansia muciniphila colonizes the mucus layer of the gastrointestinal tract, where the
organism can be exposed to the oxygen that diffuses from epithelial cells. To understand …
organism can be exposed to the oxygen that diffuses from epithelial cells. To understand …
Small membrane proteins found by comparative genomics and ribosome binding site models
The correct annotation of genes encoding the smallest proteins is one of the biggest
challenges of genome annotation, and perhaps more importantly, few annotated short open …
challenges of genome annotation, and perhaps more importantly, few annotated short open …