Regulation of inflammation by the antioxidant haem oxygenase 1
Abstract Haem oxygenase 1 (HO-1), an inducible enzyme responsible for the breakdown of
haem, is primarily considered an antioxidant, and has long been overlooked by …
haem, is primarily considered an antioxidant, and has long been overlooked by …
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 …
KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential
E Crisman, P Duarte, E Dauden… - Medicinal research …, 2023 - Wiley Online Library
The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the
master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective …
master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective …
[HTML][HTML] COVID-19 and COPD: a narrative review of the basic science and clinical outcomes
The 2019 coronavirus disease (COVID-19) pandemic is caused by severe acute respiratory
syndrome-coronavirus-2 (SARS-CoV-2). Clinical outcomes, including mortality, are worse in …
syndrome-coronavirus-2 (SARS-CoV-2). Clinical outcomes, including mortality, are worse in …
The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia
GB Kitchen, PS Cunningham… - Proceedings of the …, 2020 - National Acad Sciences
The circadian clock regulates many aspects of immunity. Bacterial infections are affected by
time of day, but the mechanisms involved remain undefined. Here we show that loss of the …
time of day, but the mechanisms involved remain undefined. Here we show that loss of the …
Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages
KBR Belchamber, R Singh, CM Batista… - European …, 2019 - Eur Respiratory Soc
Increased reactive oxygen species (ROS) have been implicated in the pathophysiology of
chronic obstructive pulmonary disease (COPD). This study examined the effect of …
chronic obstructive pulmonary disease (COPD). This study examined the effect of …
NRF2 activation reprograms defects in oxidative metabolism to restore macrophage function in chronic obstructive pulmonary disease
EM Ryan, P Sadiku, P Coelho, ER Watts… - American journal of …, 2023 - atsjournals.org
Rationale: Chronic obstructive pulmonary disease (COPD) is a disease characterized by
persistent airway inflammation and disordered macrophage function. The extent to which …
persistent airway inflammation and disordered macrophage function. The extent to which …
Pre-clinical neuroprotective evidences and plausible mechanisms of Sulforaphane in Alzheimer's disease
J Kim - International journal of molecular sciences, 2021 - mdpi.com
Sulforaphane, a potent dietary bioactive agent obtainable from cruciferous vegetables, has
been extensively studied for its effects in disease prevention and therapy. Sulforaphane …
been extensively studied for its effects in disease prevention and therapy. Sulforaphane …
[HTML][HTML] Advances in develo** noncovalent small molecules targeting Keap1
Highlights•The Keap1-Nrf2 interaction is a major regulator of antioxidant and
antiinflammatory proteins.•Keap1-Nrf2 inhibitors activate Nrf2 leading to cytoprotection.• …
antiinflammatory proteins.•Keap1-Nrf2 inhibitors activate Nrf2 leading to cytoprotection.• …
The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD
Chronic obstructive pulmonary disease (COPD) is a disease of the airways and lungs due to
an enhanced inflammatory response, commonly caused by cigarette smoking. Patients with …
an enhanced inflammatory response, commonly caused by cigarette smoking. Patients with …