The incidence and mortality rate of cancer has been quickly increasing in the past decades.
At present, cancer has become the leading cause of death worldwide. Most of the cancers …

Bladder cancer (BLCA) is one of the most common types of malignant tumors of the
urogenital system in adults. Globally, the incidence of BLCA is more than 500,000 new …

Intratumoral heterogeneity (ITH) is a fundamental property of cancer; however, the origins of
ITH remain poorly understood. We performed single-cell transcriptome profiling of peritoneal …

The ten-eleven translocation (TET) family of dioxygenases maintain stable local DNA
demethylation during cell division and lineage specification. As the major catalytic product of …

Exponential accumulation of single-cell transcriptomes poses great challenge for efficient
assimilation. Here, we present an approach entitled generative pretraining from …

Introduction: Transforming growth factor-beta (TGFβ) signaling plays a vital role in lung
adenocarcinoma (LUAD) progression. However, the involvement of TGFβ-regulated long …

Abstract Background Tumour Necrosis Factor (TNF) family members play important roles in
mounting anti-tumour immune responses, and clinical trials targeting these molecules are …