The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin)
and myelin phenotypes, which are specialized to meet the needs of small and large …

Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …

Myelinated nerve fibers are essential for the rapid propagation of action potentials by
saltatory conduction. They form as the result of reciprocal interactions between axons and …

Do young and old protein molecules have the same probability to be degraded? We
addressed this question using metabolic pulse-chase labeling and quantitative mass …

In the peripheral nervous system, Schwann cells are glial cells that are in intimate contact
with axons throughout development. Schwann cells generate the insulating myelin sheath …

Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic
stem cell (HSC) niche in the bone marrow of long bones. However, their developmental …

Peripheral nerves and Schwann cells have to sustain constant mechanical constraints,
caused by developmental growth as well as stretches associated with movements of the …

Myelinating cells surround axons to accelerate the propagation of action potentials, to
support axonal health, and to refine neural circuits. Myelination is metabolically demanding …

Glial cells in the peripheral nervous system (PNS), which arise from the neural crest, include
axon-associated Schwann cells (SCs) in nerves, synapse-associated SCs at the …