Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental
roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a …

Glucose metabolism reprogramming, which is a well‐established characteristic of multiple
cancers, demands a higher rate of glycolysis to meet the increasing demands for …

Two mechanisms have been proposed for the function of motor proteins: The power stroke
and the Brownian ratchet. The former refers to generation of a large downhill free energy …

The microtubule cytoskeleton is assembled from a finite pool of α, β-tubulin, the size of which
is controlled by an autoregulation mechanism. Cells also tightly regulate the architecture …

During cell division, mitotic motors organize microtubules in the bipolar spindle into either
polar arrays at the spindle poles or a" nematic" network of aligned microtubules at the …

Centrosomes are the canonical microtubule organizing centers (MTOCs) of most
mammalian cells, including spermatocytes. Centrosomes comprise a centriole pair within a …

Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer
cells often display centrosome amplification. To maintain survival, cancer cells achieve …

Neuronal dendrites are characterized by an anti-parallel microtubule organization. The
mixed oriented microtubules promote dendrite development and facilitate polarized cargo …

Cellular functioning relies on active transport of organelles by molecular motors. To explore
how intracellular organelle distributions affect cellular functions, several optogenetic …

Dynamic organization of microtubule minus ends is vital for the formation and maintenance
of acentrosomal microtubule arrays. In vitro, both microtubule ends switch between phases …