Engineered human cardiac tissues facilitate progress in regenerative medicine, disease
modelling and drug development. In this Perspective, we reflect on the most notable …

An ensemble of in vitro cardiac tissue models has been developed over the past several
decades to aid our understanding of complex cardiovascular disorders using a reductionist …

Functional vasculature is essential for delivering nutrients, oxygen, and cells to the heart and
removing waste products. Here, we developed an in vitro vascularized human cardiac …

Arrhythmogenic cardiomyopathy (ACM) is an inherited progressive cardiac disease. Many
patients with ACM harbor mutations in desmosomal genes, predominantly in plakophilin-2 …

Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …

Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes.
Although the steps leading up to the proliferation of surviving cardiomyocytes have been …

Friedreich ataxia (FRDA) is a rare, inherited neurodegenerative disease caused by an
expanded GAA repeat in the first intron of the FXN gene, leading to transcriptional silencing …

Human pluripotent stem cell (hPSC) technology has offered nearly infinite opportunities to
model all kinds of human diseases in vitro. Cardiomyocytes derived from hPSCs have …

Current in vivo and in vitro models fail to accurately recapitulate the human heart
microenvironment for biomedical applications. This study explores the use of cardiac …

Recent years have seen the creation and popularization of various complex in vitro models
(CIVMs), such as organoids and organs-on-chip, as a technology with the potential to …