Lipid vesicle-based molecular robots

Z Peng, S Iwabuchi, K Izumi, S Takiguchi, M Yamaji… - Lab on a Chip, 2024 - pubs.rsc.org
A molecular robot, which is a system comprised of one or more molecular machines and
computers, can execute sophisticated tasks in many fields that span from nanomedicine to …

Co-transcriptional production of programmable RNA condensates and synthetic organelles

G Fabrini, N Farag, SP Nuccio, S Li, JM Stewart… - Nature …, 2024 - nature.com
Condensation of RNA and proteins is central to cellular functions, and the ability to program
it would be valuable in synthetic biology and synthetic cell science. Here we introduce a …

Synthetic Immunology—Building Immunity from the Bottom‐Up with Synthetic Cells

O Staufer - Advanced NanoBiomed Research, 2024 - Wiley Online Library
Synthetic cells can advance immunotherapy, offering innovative approaches to
understanding and enhancing immune responses. This review article delves into the …

Sculpting DNA-based synthetic cells through phase separation and phase-targeted activity

L Malouf, DA Tanase, G Fabrini, RA Brady… - Chem, 2023 - cell.com
Synthetic cells, like their biological counterparts, require internal compartments with distinct
chemical and physical properties where different functionalities can be localized. Inspired by …

Interrogation of RNA-protein interaction dynamics in bacterial growth

M Monti, R Herman, L Mancini… - Molecular systems …, 2024 - embopress.org
Characterising RNA–protein interaction dynamics is fundamental to understand how
bacteria respond to their environment. In this study, we have analysed the dynamics of 91 …

Enzyme-Responsive DNA Condensates

J Bucci, L Malouf, DA Tanase, N Farag… - Journal of the …, 2024 - ACS Publications
Membrane-less compartments and organelles are widely acknowledged for their role in
regulating cellular processes, and there is an urgent need to harness their full potential as …

Protocell Communication through the Eyes of Synthetic Organic Chemists

A Rebasa‐Vallverdu, S Valente… - European Journal of …, 2023 - Wiley Online Library
The bottom‐up fabrication of synthetic cells (protocells) from molecules and materials, is a
major challenge of modern chemistry. A significant breakthrough has been the engineering …

Preprint Highlight: A synthetic signaling network imitating the action of immune cells in response to bacterial metabolism

JA De Lora - Molecular Biology of the Cell, 2023 - molbiolcell.org
Synthetic cells, built using approaches from bottom-up synthetic biology, aim to mimic
biological functions of their natural counterparts. However, engineering multilevel …