Metabolic costs are central to individual energy budgets, making estimates of metabolic rate
vital to understanding how an organism interacts with its environment as well as the role of …

Significance: Cancer is frequently associated with the early appearance of cachexia, a
multifactorial wasting syndrome. If not present at diagnosis, cachexia develops either as a …

In response to disturbed mitochondrial gene expression and protein synthesis, an adaptive
transcriptional response sharing a signature of the integrated stress response (ISR) is …

T cell stimulation is metabolically demanding. To exit quiescence, T cells rely on
environmental nutrients, including glucose and the amino acids glutamine, leucine, serine …

Regulation of RNA processing contributes profoundly to tissue development and physiology.
Here, we report that serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte …

Insulin deficiency and uncontrolled diabetes lead to a catabolic state with decreased muscle
strength, contributing to disease-related morbidity. FoxO transcription factors are suppressed …

Stem cells in plants constantly supply daughter cells to form new organs and are expected to
safeguard the integrity of the cells from biological invasion. Here, we show how stem cells of …

Background Cancer cachexia occurs in approximately 80% of cancer patients and is a key
contributor to cancer‐related death. The mechanisms controlling development of tumour …

Cancer cachexia is a multifactorial syndrome characterized by anorexia, body wasting, and
muscle and adipose tissue loss, impairing patient's tolerance to anticancer treatments and …

Sarcopenia and frailty are urgent socio-economic problems worldwide. Here we
demonstrate a functional connection between the lateral hypothalamus (LH) and skeletal …