Current directions in the auricular vagus nerve stimulation I–a physiological perspective

E Kaniusas, S Kampusch, M Tittgemeyer… - Frontiers in …, 2019 - frontiersin.org
Electrical stimulation of the auricular vagus nerve (aVNS) is an emerging technology in the
field of bioelectronic medicine with applications in therapy. Modulation of the afferent vagus …

Manipulation of the inflammatory reflex as a therapeutic strategy

MJ Kelly, C Breathnach, KJ Tracey, SC Donnelly - Cell Reports Medicine, 2022 - cell.com
The cholinergic anti-inflammatory pathway is the efferent arm of the inflammatory reflex, a
neural circuit through which the CNS can modulate peripheral immune responses. Signals …

Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms

Y Wang, G Zhan, Z Cai, B Jiao, Y Zhao, S Li… - … & Biobehavioral Reviews, 2021 - Elsevier
Brain diseases, including neurodegenerative, cerebrovascular and neuropsychiatric
diseases, have posed a deleterious threat to human health and brought a great burden to …

Parametric characterization of neural activity in the locus coeruleus in response to vagus nerve stimulation

DR Hulsey, JR Riley, KW Loerwald… - Experimental …, 2017 - Elsevier
Vagus nerve stimulation (VNS) has emerged as a therapy to treat a wide range of
neurological disorders, including epilepsy, depression, stroke, and tinnitus. Activation of …

Safety, feasibility, and efficacy of vagus nerve stimulation paired with upper-limb rehabilitation after ischemic stroke

J Dawson, D Pierce, A Dixit, TJ Kimberley… - Stroke, 2016 - Am Heart Assoc
Background and Purpose—Recent animal studies demonstrate that vagus nerve stimulation
(VNS) paired with movement induces movement-specific plasticity in motor cortex and …

A review of parameter settings for invasive and non-invasive vagus nerve stimulation (VNS) applied in neurological and psychiatric disorders

SL Thompson, GH O'Leary, CW Austelle… - Frontiers in …, 2021 - frontiersin.org
Vagus nerve stimulation (VNS) is an established form of neuromodulation with a long history
of promising applications. Earliest reports of VNS in the literature date to the late 1800's in …

Vagus nerve stimulation enhances stable plasticity and generalization of stroke recovery

EC Meyers, BR Solorzano, J James, PD Ganzer… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Chronic impairment of the arm and hand is a common
consequence of stroke. Animal and human studies indicate that brief bursts of vagus nerve …

Targeted vagus nerve stimulation for rehabilitation after stroke

ND Engineer, TJ Kimberley, CN Prudente… - Frontiers in …, 2019 - frontiersin.org
Stroke is a leading cause of disability worldwide, and in approximately 60% of individuals,
upper limb deficits persist 6 months after stroke. These deficits adversely affect the functional …

Vagus nerve stimulation and the cardiovascular system

MJ Capilupi, SM Kerath… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
The vagus nerve plays an important role in maintaining physiological homeostasis, which
includes reflex pathways that regulate cardiac function. The link between vagus nerve …

Advanced neurotechnologies for the restoration of motor function

S Micera, M Caleo, C Chisari, FC Hummel, A Pedrocchi - Neuron, 2020 - cell.com
Stroke is one of the leading causes of long-term disability. Advanced technological solutions
(" neurotechnologies") exploiting robotic systems and electrodes that stimulate the nervous …