Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made
in the elucidation of the pathogenesis of its protean complications, which has inspired recent …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …

Immune thrombotic thrombocytopenic purpura (iTTP) survivors have increased risk of
cardiovascular disease, including strokes, and report persistent cognitive difficulties during …

Cerebral infarction is a common complication of sickle cell disease and may manifest as
overt stroke or cognitive impairment associated with “silent” cerebral infarction on magnetic …

Aim Sickle cell disease (SCD) is the commonest cause of childhood stroke worldwide.
Magnetic resonance imaging (MRI) is routinely used to detect additional silent cerebral …

Sustained donor engraftment after allogeneic hematopoietic cell transplantation (HCT)
converts to healthy donor hemoglobin synthesis and halts disease symptoms in patients with …

Background and purpose Silent cerebral infarcts (SCIs) are the most common neurological
complication in children and adults with sickle cell disease (SCD). In this systematic review …

Sickle cell disease is characterized by chronic hemolytic anemia and vascular inflammation,
which can diminish the vasodilatory capacity of the small resistance arteries, making them …

In sickle cell disease (SCD), oxygen delivery is impaired due to anemia, especially during
times of increased metabolic demand, and cerebral blood flow (CBF) must increase to meet …

Background Sickle cell disease (SCD) is a type of hemoglobinopathy characterized by
abnormal hemoglobin molecules, which includes numerous acute and chronic …