Antiviral restriction factors are host cellular proteins that constitute a first line of defense
blocking viral replication and propagation. In addition to interfering at critical steps of the …

Protective immune responses to viral infection are initiated by innate immune sensors that
survey extracellular and intracellular space for foreign nucleic acids. The existence of these …

DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by
CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP …

Sterile alpha motif and HD-domain–containing protein 1 (SAMHD1) blocks replication of
retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has …

N 6-methyladenosine (m6A) is a prevalent RNA modification that plays a key role in
regulating eukaryotic cellular mRNA functions. RNA m6A modification is regulated by two …

Recognition of pathogen-derived foreign nucleic acids is central to innate immune defense.
This requires discrimination between structurally highly similar self and nonself nucleic acids …

The internal N 6-methyladenosine (m 6 A) modification of cellular mRNA regulates post-
transcriptional gene expression. The YTH domain family proteins (YTHDF1–3 or Y1–3) bind …

Defects in nucleic acid metabolizing enzymes can lead to spontaneous but selective
activation of either cGAS/STING or RIG-like receptor (RLR) signaling, causing type I …

Antiviral restriction factors are cellular proteins that inhibit the entry, replication, or spread of
viruses. These proteins are critical components of the innate immune system and function to …

Deoxynucleoside triphosphate (dNTP) molecules are essential for the replication and
maintenance of genomic information in both cells and a variety of viral pathogens. While the …