Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
The mononuclear phagocyte system (MPS) has historically been categorized into
monocytes, dendritic cells and macrophages on the basis of functional and phenotypical …
monocytes, dendritic cells and macrophages on the basis of functional and phenotypical …
Dendritic cells revisited
M Cabeza-Cabrerizo, A Cardoso… - Annual review of …, 2021 - annualreviews.org
Dendritic cells (DCs) possess the ability to integrate information about their environment and
communicate it to other leukocytes, sha** adaptive and innate immunity. Over the years, a …
communicate it to other leukocytes, sha** adaptive and innate immunity. Over the years, a …
ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut
Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell
responses, but the mechanisms controlling these distinct outcomes remain poorly …
responses, but the mechanisms controlling these distinct outcomes remain poorly …
The cellular and molecular origin of tumor-associated macrophages
RA Franklin, W Liao, A Sarkar, MV Kim, MR Bivona… - Science, 2014 - science.org
Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and
immune defense against pathogens, macrophages are being rediscovered as regulators of …
immune defense against pathogens, macrophages are being rediscovered as regulators of …
C-type lectins in immunity and homeostasis
GD Brown, JA Willment, L Whitehead - Nature Reviews Immunology, 2018 - nature.com
The C-type lectins are a superfamily of proteins that recognize a broad repertoire of ligands
and that regulate a diverse range of physiological functions. Most research attention has …
and that regulate a diverse range of physiological functions. Most research attention has …
PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer
Inhibiting the programmed death-1 (PD-1) pathway is one of the most effective approaches
to cancer immunotherapy, but its mechanistic basis remains incompletely understood …
to cancer immunotherapy, but its mechanistic basis remains incompletely understood …
Genetic models of human and mouse dendritic cell development and function
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …
numerous shared characteristics between mice and humans. Human counterparts of mouse …
GM-CSF mouse bone marrow cultures comprise a heterogeneous population of CD11c+ MHCII+ macrophages and dendritic cells
Dendritic cells (DCs) are key players in the immune system. Much of their biology has been
elucidated via culture systems in which hematopoietic precursors differentiate into DCs …
elucidated via culture systems in which hematopoietic precursors differentiate into DCs …
Mechanisms regulating skin immunity and inflammation
M Pasparakis, I Haase, FO Nestle - Nature reviews immunology, 2014 - nature.com
Immune responses in the skin are important for host defence against pathogenic
microorganisms. However, dysregulated immune reactions can cause chronic inflammatory …
microorganisms. However, dysregulated immune reactions can cause chronic inflammatory …
Tumor-derived prostaglandin E2 programs cDC1 dysfunction to impair intratumoral orchestration of anti-cancer T cell responses
F Bayerl, P Meiser, S Donakonda, A Hirschberger… - Immunity, 2023 - cell.com
Type 1 conventional dendritic cells (cDC1s) are critical for anti-cancer immunity. Protective
anti-cancer immunity is thought to require cDC1s to sustain T cell responses within tumors …
anti-cancer immunity is thought to require cDC1s to sustain T cell responses within tumors …