The identification and detection of disease-related biomarkers is essential for early clinical
diagnosis, evaluating disease progression, and for the development of therapeutics …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Fluorescence imaging is one of the most promising approaches to achieve intraoperative
assessment of the tumor/normal tissue margins during cancer surgery. This is critical to …

The discovery of a near-infrared (NIR, 650–900 nm) fluorescent chromophore hemicyanine
dye with high structural tailorability is of great significance in the field of detection …

Cellular senescence is a physiological mechanism whereby a proliferating cell undergoes a
stable cell cycle arrest upon damage or stress and elicits a secretory phenotype. This highly …

Small-molecule based fluorescent probes are increasingly important for the detection and
imaging of biological signaling molecules due to their simplicity, high selectivity and …

Optical nanoparticles are promising diagnostic tools; however, their shallow optical imaging
depth and slow clearance from the body have impeded their use for in vivo disease …

Polymers have been widely applied in various fields in the daily routines and the
manufacturing. Despite the awareness of the aggressive and inevitable aging for the …

The real-time, dynamic optical visualization of lesions and margins ensures not only
complete resection of the malignant tissues but also better preservation of the vital …

Activity of β-galactosidase at pH 6 is a classic maker of senescence in cellular biology.
Cellular senescence, a state of highly stable cell cycle arrest, is often compared to apoptosis …