[HTML][HTML] Classical renin-angiotensin system in kidney physiology
The renin-angiotensin system has powerful effects in control of the blood pressure and
sodium homeostasis. These actions are coordinated through integrated actions in the …
sodium homeostasis. These actions are coordinated through integrated actions in the …
The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
Discovered more than 30 years ago, the angiotensin AT 2 receptor (AT 2 R) has evolved
from a binding site with unknown function to a firmly established major effector within the …
from a binding site with unknown function to a firmly established major effector within the …
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a
IR Chassagnon, CA McCarthy… - Proceedings of the …, 2017 - National Acad Sciences
Stroke is the second-leading cause of death worldwide, yet there are no drugs available to
protect the brain from stroke-induced neuronal injury. Acid-sensing ion channel 1a (ASIC1a) …
protect the brain from stroke-induced neuronal injury. Acid-sensing ion channel 1a (ASIC1a) …
Modulation of angiotensin II signaling in the prevention of fibrosis
Over the last decade, it has become clear that the role of angiotensin II extends far beyond
recognized renal and cardiovascular effects. The presence of an autologous renin …
recognized renal and cardiovascular effects. The presence of an autologous renin …
Targeting renin–angiotensin system against Alzheimer's disease
Renin Angiotensin System (RAS) is a hormonal system that regulates blood pressure and
fluid balance through a coordinated action of renal, cardiovascular, and central nervous …
fluid balance through a coordinated action of renal, cardiovascular, and central nervous …
[HTML][HTML] The renin angiotensin system as a therapeutic target in traumatic brain injury
Traumatic brain injury (TBI) is a major public health problem, with limited pharmacological
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …
options available beyond symptomatic relief. The renin angiotensin system (RAS) is …
Recent advances involving the renin–angiotensin system
SD Crowley, TM Coffman - Experimental cell research, 2012 - Elsevier
The renin–angiotensin system (RAS) exercises fundamental control over sodium and water
handling in the kidney. Accordingly, dysregulation of the RAS leads to blood pressure …
handling in the kidney. Accordingly, dysregulation of the RAS leads to blood pressure …
Inhibition of insulin-regulated aminopeptidase confers neuroprotection in a conscious model of ischemic stroke
Stroke is a leading cause of mortality and morbidity with a paucity of effective
pharmacological treatments. We have previously identified insulin-regulated …
pharmacological treatments. We have previously identified insulin-regulated …
AT2 receptor activities and pathophysiological implications
LC Matavelli, HM Siragy - Journal of cardiovascular pharmacology, 2015 - journals.lww.com
Although angiotensin II subtype-2 receptor (AT2R) was discovered over 2 decades ago, its
contribution to physiology and pathophysiology is not fully elucidated. Current knowledge …
contribution to physiology and pathophysiology is not fully elucidated. Current knowledge …
Animal models of ischaemic stroke and characterisation of the ischaemic penumbra
C McCabe, MM Arroja, E Reid, IM Macrae - Neuropharmacology, 2018 - Elsevier
Over the past forty years, animal models of focal cerebral ischaemia have allowed us to
identify the critical cerebral blood flow thresholds responsible for irreversible cell death …
identify the critical cerebral blood flow thresholds responsible for irreversible cell death …