Sesquiterpenoids lactones: benefits to plants and people

M Chadwick, H Trewin, F Gawthrop… - International journal of …, 2013 - mdpi.com
Sesquiterpenoids, and specifically sesquiterpene lactones from Asteraceae, may play a
highly significant role in human health, both as part of a balanced diet and as …

What made sesquiterpene lactones reach cancer clinical trials?

A Ghantous, H Gali-Muhtasib, H Vuorela, NA Saliba… - Drug discovery today, 2010 - Elsevier
Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional
medicine against inflammation and cancer. This review focuses on the chemical and …

Cinnamic acid derivatives as anticancer agents-a review

P De, M Baltas, F Bedos-Belval - Current medicinal chemistry, 2011 - ingentaconnect.com
Cinnamic acid and its phenolic analogues are natural substances. Chemically, in cinnamic
acids the 3-phenyl acrylic acid functionality offers three main reactive sites; substitution at …

Biological activities of sesquiterpene lactones

AK Picman - Biochemical systematics and Ecology, 1986 - Elsevier
Although sesquiterpene lactones are terpenoid compounds characteristic of the Asteraceae
(Compositae) they are also known from other angiosperm families as well as from some …

Biological activities of sesquiterpene lactones

E Rodriguez, GHN Towers, JC Mitchell - Phytochemistry, 1976 - Elsevier
Sesquiterpene lactones are characteristic constituents of the Compositae but also occur
sporadically in other angiosperm families and even in some liverworts. These bitter …

Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms

S Zhang, YK Won, CN Ong… - … Medicinal Chemistry-Anti …, 2005 - ingentaconnect.com
Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants
used in traditional medicine for the treatment of inflammatory diseases. In recent years, the …

Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach

KH Lee - Journal of natural products, 2010 - ACS Publications
Medicinal plants have long been an excellent source of pharmaceutical agents. Accordingly,
the long-term objectives of the author's research program are to discover and design new …

Development of anticancer agents from plant-derived sesquiterpene lactones

Y Ren, J Yu, A Douglas Kinghorn - Current medicinal chemistry, 2016 - ingentaconnect.com
Sesquiterpene lactones are of considerable interest due to their potent bioactivities,
including cancer cell cytotoxicity and antineoplastic efficacy in in vivo studies. Among these …

Sesquiterpene lactones as drugs with multiple targets in cancer treatment: focus on parthenolide

MRO Kreuger, S Grootjans, MW Biavatti… - Anti-cancer …, 2012 - journals.lww.com
Sesquiterpene lactones (SLs) constitute a large and diverse group of biologically active
plant compounds that possess anti-inflammatory and antitumor activity. The subclass …

Antitumor agents. Part 202: novel 2′-amino chalcones: design, synthesis and biological evaluation

Y **a, ZY Yang, P **a, KF Bastow, Y Nakanishi… - Bioorganic & medicinal …, 2000 - Elsevier
New 4′, 5′, 2, 3, 4-substituted 2′-amino chalcones were synthesized and evaluated for
cytotoxicity against a panel of human tumor cell lines. Several compounds displayed …