Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

C Gao, J Jiang, Y Tan, S Chen - Signal transduction and targeted …, 2023 - nature.com
Microglia activation is observed in various neurodegenerative diseases. Recent advances in
single-cell technologies have revealed that these reactive microglia were with high spatial …

Immune response following traumatic spinal cord injury: Pathophysiology and therapies

RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

[HTML][HTML] Integrating the neurodevelopmental and dopamine hypotheses of schizophrenia and the role of cortical excitation-inhibition balance

OD Howes, E Shatalina - Biological psychiatry, 2022 - Elsevier
The neurodevelopmental and dopamine hypotheses are leading theories of the
pathoetiology of schizophrenia, but they were developed in isolation. However, since they …

The biphasic function of microglia in ischemic stroke

Y Ma, J Wang, Y Wang, GY Yang - Progress in neurobiology, 2017 - Elsevier
Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

Genetic contribution to microglial activation in schizophrenia

M Koskuvi, E Pörsti, T Hewitt, N Räsänen, YC Wu… - Molecular …, 2024 - nature.com
Several lines of evidence indicate the involvement of neuroinflammatory processes in the
pathophysiology of schizophrenia (SCZ). Microglia are brain resident immune cells …

[HTML][HTML] Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for develo** new therapies for TBI. Current treatments for TBI are primarily focused …

Obesity and neuroinflammation: a pathway to cognitive impairment

AA Miller, SJ Spencer - Brain, behavior, and immunity, 2014 - Elsevier
Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

Microglia regulate the number of neural precursor cells in the develo** cerebral cortex

CL Cunningham, V Martínez-Cerdeño… - Journal of …, 2013 - jneurosci.org
Neurogenesis must be properly regulated to ensure that cell production does not exceed the
requirements of the growing cerebral cortex, yet our understanding of mechanisms that …

Minocycline: far beyond an antibiotic

N Garrido‐Mesa, A Zarzuelo… - British journal of …, 2013 - Wiley Online Library
Minocycline is a second‐generation, semi‐synthetic tetracycline that has been in therapeutic
use for over 30 years because of its antibiotic properties against both gram‐positive and …

The impact of microglial activation on blood-brain barrier in brain diseases

ACC da Fonseca, D Matias, C Garcia… - Frontiers in cellular …, 2014 - frontiersin.org
The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs)
together with neurons and glial cells, including microglia, forms the neurovascular unit …