For many years cancer research has focused on genetic defects, but during the last decade
epigenetic deregulation has been increasingly recognized as a hallmark of cancer. The …

Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the
lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed …

Background Although aberrant DNA methylation has been observed previously in acute
lymphoblastic leukemia (ALL), the patterns of differential methylation have not been …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive desmoplasia,
which challenges the molecular analyses of bulk tumor samples. Here we FACS-purified …

The importance of epigenetic modifications such as DNA methylation in tumorigenesis is
increasingly being appreciated. To define the genome‐wide pattern of DNA methylation in …

Sex differences in methylation status have been observed in specific gene-disease studies
and healthy methylation variation studies, but little work has been done to study the impact …

Biomarkers play an essential role in the management of patients with invasive cancers.
Pancreatic ductal adenocarcinoma (PDC) associated with poor prognosis due to advanced …

Background Histologic characteristics have proven to be very useful for classifying different
types of tumors of the pancreas. As a result, the major tumor types in the pancreas have long …

The epigenomic abnormality of pancreatic ductal adenocarcinoma (PDAC) has rarely been
investigated due to its strong heterogeneity. Here, we used single-cell multiomics …

Purpose: The goal of this study was to comprehensively identify CpG island methylation
alterations between pancreatic cancers and normal pancreata and their associated gene …