Hydroxamic acids− an intriguing family of enzyme inhibitors and biomedical ligands

CJ Marmion, D Griffith, KB Nolan - European Journal of …, 2004 - Wiley Online Library
This review on hydroxamic acids deals with their efficacy as inhibitors of enzymes including
cyclooxygenases, their synthesis, the complexity and structural diversity of their metal …

Development of Inhibitors of the 2C-Methyl-d-erythritol 4-Phosphate (MEP) Pathway Enzymes as Potential Anti-Infective Agents

T Masini, AKH Hirsch - Journal of medicinal chemistry, 2014 - ACS Publications
Important pathogens such as Mycobacterium tuberculosis and Plasmodium falciparum, the
causative agents of tuberculosis and malaria, respectively, and plants, utilize the 2 C-methyl …

Removal of benzohydroxamic acid-metal complexes pollution from beneficiation wastewater by metal-biochar/peroxymonosulfate system: Behaviors investigation and …

M Li, J Wang, H Shen, Z He, H Zhong, W Sun… - Chemical Engineering …, 2023 - Elsevier
The organometal complexes pollution in beneficiation wastewater has aroused increasing
attentions because they were difficult to remove by traditional technologies. In this study …

Zinc-dependent deacetylase (HDAC) inhibitors with different zinc binding groups

Y Li, F Wang, X Chen, J Wang, Y Zhao… - Current topics in …, 2019 - ingentaconnect.com
The state of histone acetylation plays a very crucial role in carcinogenesis and its
development by chromatin remodeling and thus altering transcription of oncogenes and …

The design of inhibitors for medicinally relevant metalloproteins

FE Jacobsen, JA Lewis… - … : Chemistry Enabling Drug …, 2007 - Wiley Online Library
A number of metalloproteins are important medicinal targets for conditions ranging from
pathogenic infections to cancer. Many but not all of these metalloproteins contain a zinc (II) …

Oxalic acid drove the permutation decomplexation of the Fe-salicylhydroxamic acid complex and the photocatalytic removal of salicylhydroxamic acid

Y Cao, W Pang, J Yao, Z Li, J Su, W Zhang… - Separation and …, 2024 - Elsevier
Residual salicylhydroxamic acid (SHA) and Fe 3+ in mining sites often form stable, toxic Fe
3+-SHA complexes that are hard to remove and ecologically risky. There's an urgent need …

3-Hydroxypyridin-2-thione as novel zinc binding group for selective histone deacetylase inhibition

V Patil, QH Sodji, JR Kornacki, M Mrksich… - Journal of medicinal …, 2013 - ACS Publications
Small molecules bearing hydroxamic acid as the zinc binding group (ZBG) have been the
most effective histone deacetylase inhibitors (HDACi) to date. However, concerns about the …

“Tag and modify” protein conjugation with dynamic covalent chemistry

MM Zegota, T Wang, C Seidler, DY Wah Ng… - Bioconjugate …, 2018 - ACS Publications
The development of small protein tags that exhibit bioorthogonality, bond stability, and
reversibility, as well as biocompatibility, holds great promise for applications in cellular …

QSAR studies on hydroxamic acids: a fascinating family of chemicals with a wide spectrum of activities

SP Gupta - Chemical reviews, 2015 - ACS Publications
Hydroxamic acids constitute a unique family of chemicals with multiple biological activities,
because they act as potent and selective inhibitors of a large number of enzymes, such as …

Hydroxamic acid–A novel molecule for anticancer therapy

D Pal, S Saha - Journal of advanced pharmaceutical technology & …, 2012 - journals.lww.com
Hydroxamic acid is a potent moiety not only in the field of cancer therapy but also as a
mutagenic agent. Among the various derivatives of hydroxamic acid, SAHA (Suberoylanilide …