Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF)
contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its …

Intense genome sequencing of Pseudomonas aeruginosa isolates from cystic fibrosis (CF)
airways has shown inefficient eradication of the infecting bacteria, as well as previously …

Executive summary The past six decades have seen remarkable improvements in health
outcomes for people with cystic fibrosis, which was once a fatal disease of infants and young …

In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

The chronic infection hypothesis for novel severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) variant emergence is increasingly gaining credence following the …

Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …

Lung infections with Mycobacterium abscessus, a species of multidrug-resistant
nontuberculous mycobacteria, are emerging as an important global threat to individuals with …

Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute
and chronic infections. β-lactam antibiotics including penicillins, carbapenems …

What enables strains of the same species to coexist in a microbiome? Here, we investigate
whether host anatomy can explain strain co-residence of Cutibacterium acnes, the most …

Background A basic paradigm of human infection is that acute bacterial disease is caused
by fast growing planktonic bacteria while chronic infections are caused by slow-growing …