New clinical trial design in precision medicine: discovery, development and direction

XP Duan, BD Qin, XD Jiao, K Liu, Z Wang… - Signal Transduction and …, 2024‏ - nature.com
In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …

Mesothelioma: Scientific clues for prevention, diagnosis, and therapy

M Carbone, PS Adusumilli… - CA: a cancer journal …, 2019‏ - Wiley Online Library
Mesothelioma affects mostly older individuals who have been occupationally exposed to
asbestos. The global mesothelioma incidence and mortality rates are unknown, because …

Integrative molecular characterization of malignant pleural mesothelioma

J Hmeljak, F Sanchez-Vega, KA Hoadley, J Shih… - Cancer …, 2018‏ - aacrjournals.org
Malignant pleural mesothelioma (MPM) is a highly lethal cancer of the lining of the chest
cavity. To expand our understanding of MPM, we conducted a comprehensive integrated …

ALK fusions in the pan-cancer setting: another tumor-agnostic target?

A Shreenivas, F Janku, MA Gouda, HZ Chen… - NPJ Precision …, 2023‏ - nature.com
Anaplastic lymphoma kinase (ALK) alterations (activating mutations, amplifications, and
fusions/rearrangements) occur in~ 3.3% of cancers. ALK fusions/rearrangements are …

[HTML][HTML] Pleural mesothelioma classification—update and challenges

S Dacic - Modern Pathology, 2022‏ - Elsevier
Mesothelial tumors are classified into benign or preinvasive tumors, and mesotheliomas.
The benign or preinvasive group includes adenomatoid tumors, well-differentiated papillary …

New era for malignant pleural mesothelioma: updates on therapeutic options

AS Tsao, HI Pass, A Rimner… - Journal of Clinical …, 2022‏ - ascopubs.org
Malignant pleural mesothelioma (MPM) is a rare malignancy with few treatment options.
Recent advances have led to US Food and Drug Administration approvals and changes in …

[PDF][PDF] Guidelines for pathologic diagnosis of mesothelioma: 2023 update of the consensus statement from the international mesothelioma interest group

AN Husain, DB Chapel, R Attanoos… - … of Pathology & …, 2024‏ - meridian.allenpress.com
Context.—Mesothelioma is an uncommon tumor that can be difficult to diagnose. Objective.—
To provide updated, practical guidelines for the pathologic diagnosis of mesothelioma. Data …

[HTML][HTML] Second Paediatric Strategy Forum for anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies: ACCELERATE in collaboration with the …

ADJ Pearson, E Barry, YP Mossé, F Ligas… - European Journal of …, 2021‏ - Elsevier
Abstract The first (2017) and sixth (2021) multistakeholder Paediatric Strategy Forums
focused on anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies. ALK is …

Malignant peritoneal mesothelioma: a review

G Broeckx, P Pauwels - Translational lung cancer research, 2018‏ - pmc.ncbi.nlm.nih.gov
Malignant peritoneal mesothelioma (MPM) is a very rare malignancy of the peritoneum and
has a poor prognosis. Of all mesotheliomas, pleural mesothelioma is more common than …

[HTML][HTML] Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42

M Stevers, JT Rabban, K Garg, J Van Ziffle, C Onodera… - Modern Pathology, 2019‏ - Elsevier
Well-differentiated papillary mesothelioma is an uncommon mesothelial neoplasm that most
frequently arises in the peritoneal cavity of women of reproductive age. Whereas malignant …