Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

S Qin, W **ao, C Zhou, Q Pu, X Deng, L Lan… - Signal transduction and …, 2022 - nature.com
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

Surveying membrane landscapes: a new look at the bacterial cell surface

T Lithgow, CJ Stubenrauch, MPH Stumpf - Nature Reviews Microbiology, 2023 - nature.com
Recent studies applying advanced imaging techniques are changing the way we
understand bacterial cell surfaces, bringing new knowledge on everything from single-cell …

Role of the lipid bilayer in outer membrane protein folding in Gram-negative bacteria

JE Horne, DJ Brockwell, SE Radford - Journal of Biological Chemistry, 2020 - ASBMB
β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …

Bacterial AsmA-like proteins: bridging the gap in intermembrane phospholipid transport

S Kumar, N Ruiz - Contact, 2023 - journals.sagepub.com
In eukaryotic cells, nonvesicular lipid transport between organelles is mediated by lipid-
transfer proteins. Recently, a new class of these lipid transporters has been described to …

Function of the Omp85 superfamily of outer membrane protein assembly factors and polypeptide transporters

MT Doyle, HD Bernstein - Annual Review of Microbiology, 2022 - annualreviews.org
The Omp85 protein superfamily is found in the outer membrane (OM) of all gram-negative
bacteria and eukaryotic organelles of bacterial origin. Members of the family catalyze both …

YhdP, TamB, and YdbH are redundant but essential for growth and lipid homeostasis of the Gram-negative outer membrane

N Ruiz, RM Davis, S Kumar - MBio, 2021 - Am Soc Microbiol
The bacterial cell envelope is the first line of defense and point of contact with the
environment and other organisms. Envelope biogenesis is therefore crucial for the survival …

The translocation assembly module (TAM) catalyzes the assembly of bacterial outer membrane proteins in vitro

X Wang, SB Nyenhuis, HD Bernstein - Nature Communications, 2024 - nature.com
The t ranslocation and a ssembly m odule (TAM) has been proposed to play a crucial role in
the assembly of a small subset of outer membrane proteins (OMPs) in Proteobacteria based …

How bacteria establish and maintain outer membrane lipid asymmetry

WB Tan, SS Chng - Annual Review of Microbiology, 2024 - annualreviews.org
Gram-negative bacteria build an asymmetric outer membrane (OM), with
lipopolysaccharides (LPS) and phospholipids (PLs) occupying the outer and inner leaflets …

The rich tapestry of bacterial protein translocation systems

PJ Christie - The protein journal, 2019 - Springer
The translocation of proteins across membranes is a fundamental cellular function. Bacteria
have evolved a striking array of pathways for delivering proteins into or across cytoplasmic …

POTRA domains of the TamA insertase interact with the outer membrane and modulate membrane properties

A Mellouk, P Jaouen, LJ Ruel, M Lê, C Martini… - Proceedings of the …, 2024 - pnas.org
The outer membrane (OM) of gram-negative bacteria serves as a vital organelle that is
densely populated with OM proteins (OMPs) and plays pivotal roles in cellular functions and …