We review a large volume of literature concerning mathematical models of cancer therapy,
oriented towards optimization of treatment protocols. The review, although partly …

In this work we propose and investigate a family of models, which admits as particular cases
some well known mathematical models of tumor-immune system interaction, with the …

Antiangiogenic therapy is a novel treatment approach in cancer therapy that aims at
preventing a tumor from develo** its own blood supply system that it needs for growth. In …

A mathematical model for the scheduling of angiogenic inhibitors in combination with a
chemotherapeutic agent is formulated. Conditions are given that allow tumor eradication …

In this paper, we consider a three-dimensional nonlinear delay differential system (tumor
cells, cytotoxic-T lymphocytes, T-helper cells) with single interaction delay. We perform …

In this article, four different mathematical models of chemotherapy from the literature are
investigated with respect to optimal control of drug treatment schedules. The various models …

This paper investigates the dynamics of a three-dimensional nonlinear cancer model
involving interactions among cancer cells, normal cells, and immune cells. By performing a …

Although recent advances in oncology emphasized the role of microenvironment in tumor
growth, the role of delays for modeling tumor growth is still uncertain. In this paper, we …

In this article, an impulsive stochastic tumor-immune model with regime switching is
formulated and explored. Firstly, it is proven that the model has a unique global positive …

The tumor–immune system competitive interaction is very complex, being nonlinear and, to
some extent, evolutive. Furthermore, the tumor itself is not a single well defined disease, but …