Adverse drug reactions (ADRs) rank as one of the top 10 leading causes of death and
illness in developed countries. ADRs show differential features depending upon genotype …

Numerous genes for monogenic kidney diseases with classical patterns of inheritance, as
well as genes for complex kidney diseases that manifest in combination with environmental …

Background Genetic testing in CKD has recently been shown to have diagnostic utility with
many predicted implications for clinical management, but its effect on management has not …

Mounting evidence indicates that monogenic disorders are the underlying cause in a
significant proportion of chronic kidney disease patients. In recent years, the diagnostic yield …

Introduction: Chronic kidney disease (CKD) is a major public health issue in the USA.
Identification of monogenic causes of CKD, which are present in∼ 10% of adult cases, can …

Purpose The success of genomic medicine hinges on the implementation of genetic
knowledge in clinical settings. In novel subspecialties, it requires that clinicians refer patients …

Background The cause of kidney failure is unknown in approximately 10% of patients with
stage 5 chronic kidney disease (CKD). For those who first present to nephrology care with …

Rationale & Objective The identification of pathogenic variants in genes associated with
chronic kidney disease can provide patients and nephrologists with actionable information …

Genomic medicine is being implemented on a global scale, requiring a genomic-competent
health workforce. To inform education as part of implementation strategies to optimize …

Background Despite the emergence of diagnostic and clinical utility evidence in nephrology,
publicly funded access to genomic testing is restricted in most health care systems. To …