The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

Diabetes poses a significant global health challenge, necessitating innovative therapeutic
strategies. Natural products and their derivatives have emerged as promising candidates for …

Purpose Patients with diabetes mellitus (DM) are more susceptible to viral and bacterial
infections, facing a more severe prognosis and higher mortality rates. The study's main aim …

Tolerogenic dendritic cells (TolDCs) are attractive therapeutic options for autoimmune
disorders because they suppress autologous T-cell responses. Dendritic cells (DCs) are …

Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by insulin
deficiency and impaired glucose regulation. While daily insulin therapy is life-saving, many …

Aim Mendelian randomization (MR) analysis has been used in the exploration of the role of
gut microbiota (GM) in type 2 diabetes mellitus (T2DM); however, it was limited to the genus …

Abstract Heat shock protein 47 (HSP47) is a chaperone protein responsible for regulating
collagen maturation and transport, directly impacting collagen synthesis levels. Aberrant …

We have integrated dermal dendritic cell surrogates originally generated from the cell line
THP-1 as central mediators of the immune reaction in a human full-thickness skin model …

In today's pharmaceutical landscape, there's an urgent need to develop new drug delivery
systems that are appealing and effective in ensuring therapeutic adherence, particularly …