Perfluorooctane sulfonate (PFOS) is a persistent, widely present organic pollutant. PFOS
can enter the human body through drinking water, ingestion of food, contact with utensils …

The transient receptor potential melastatin subfamily member 2 (TRPM2), a thermo and
reactive oxygen species (ROS) sensitive Ca2+-permeable cation channel has a vital role in …

Drug-induced liver injury (DILI) is a widespread and harmful disease closely linked to
mitochondrial and endoplasmic reticulum stress (ERS). Globally, severe drug-induced …

Itaconate is produced by an enzyme encoded by the immune-responsive gene 1 (IRG1) and
exerts antibacterial, anti-inflammatory, and antioxidant effects via multiple mechanisms …

Reactive oxygen species (ROS) play an important role in regulating various physiological
functions by activating specific ion channels to mediate cell growth, proliferation …

Parkinson's disease (PD) is an age-related chronic neurodegenerative disease. Although
PD is known to be a result of damage to hippocampal neurons, its molecular mechanism …

Background Polydatin, a glucoside of resveratrol, has shown protective effects against
various diseases. However, little is known about its effect on hepatic ischemia-reperfusion …

Non‑alcoholic fatty liver disease (NAFLD) is a clinically progressive illness that can advance
from simple fatty liver to non-alcoholic hepatitis and liver fibrosis. Cirrhosis and …

Metabolic syndromes including atherosclerosis, diabetes, obesity, and hypertension are
increasingly prevalent worldwide. The disorders are the primary attributes of oxidative stress …

Acute liver injury (AIL), a fatal clinical disease featured with a swift deterioration of
hepatocyte functions in the short term, has emerged as a serious public health issues that …