A compendium of mutational cancer driver genes
A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to develo** more efficient cancer detection methods and …
transformation. This is key to develo** more efficient cancer detection methods and …
[HTML][HTML] The 2021 WHO classification of tumors of the thymus and mediastinum: what is new in thymic epithelial, germ cell, and mesenchymal tumors?
A Marx, JKC Chan, L Chalabreysse, S Dacic… - Journal of Thoracic …, 2022 - Elsevier
This overview of the fifth edition of the WHO classification of thymic epithelial tumors
(including thymomas, thymic carcinomas, and thymic neuroendocrine tumors [NETs]) …
(including thymomas, thymic carcinomas, and thymic neuroendocrine tumors [NETs]) …
Pembrolizumab in patients with thymic carcinoma: a single-arm, single-centre, phase 2 study
Background Treatment options are limited for patients with thymic carcinoma. These
aggressive tumours are not typically associated with paraneoplastic autoimmune disorders …
aggressive tumours are not typically associated with paraneoplastic autoimmune disorders …
Advances in the understanding of disease mechanisms of autoimmune neuromuscular junction disorders
Muscle weakness and fatigue are the hallmarks of autoimmune neuromuscular junction
disorders. Although a plethora of immunosuppressive treatments exist, no cure is available …
disorders. Although a plethora of immunosuppressive treatments exist, no cure is available …
Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma
Y Yasumizu, N Ohkura, H Murata, M Kinoshita… - Nature …, 2022 - nature.com
Myasthenia gravis (MG) is a neurological disease caused by autoantibodies against
neuromuscular-associated proteins. While MG frequently develops in thymoma patients, the …
neuromuscular-associated proteins. While MG frequently develops in thymoma patients, the …
Efficacy and tolerability of anti-programmed death-ligand 1 (PD-L1) antibody (Avelumab) treatment in advanced thymoma
Background Thymic epithelial tumors are PD-L1–expressing tumors of thymic epithelial
origin characterized by varying degrees of lymphocytic infiltration and a predisposition …
origin characterized by varying degrees of lymphocytic infiltration and a predisposition …
Thymus and autoimmunity
A Marx, Y Yamada, K Simon-Keller, B Schalke… - Seminars in …, 2021 - Springer
The thymus prevents autoimmune diseases through mechanisms that operate in the cortex
and medulla, comprising positive and negative selection and the generation of regulatory T …
and medulla, comprising positive and negative selection and the generation of regulatory T …
Avelumab plus axitinib in unresectable or metastatic type B3 thymomas and thymic carcinomas (CAVEATT): a single-arm, multicentre, phase 2 trial
Background Patients with advanced type B3 thymoma and thymic carcinoma resistant to
chemotherapy have few treatment options. We report the efficacy and safety results of the …
chemotherapy have few treatment options. We report the efficacy and safety results of the …
[HTML][HTML] Reprint of “Introduction to 2021 WHO Classification of Thoracic Tumors”
The WHO classification system of tumors is adopted worldwide and is fundamental to how
tumor or tumor-like conditions are clinically managed or treated. It is considered the …
tumor or tumor-like conditions are clinically managed or treated. It is considered the …
Thymic carcinomas—a concise multidisciplinary update on recent developments from the Thymic Carcinoma Working Group of the International Thymic Malignancy …
Thymic carcinomas are rare malignancies that in general arise in the prevascular (anterior)
mediastinum. These tumors are usually invasive, often present at advanced stages, and …
mediastinum. These tumors are usually invasive, often present at advanced stages, and …