[HTML][HTML] Pathophysiology and mechanisms of primary sarcopenia

H Nishikawa, S Fukunishi, A Asai… - International …, 2021 - spandidos-publications.com
Aging causes skeletal muscle atrophy, and myofiber loss can be a critical component of this
process. In 1989, Rosenberg emphasized the importance of the loss of skeletal muscle …

Sarcopenia, frailty and their prevention by exercise

CM Nascimento, M Ingles, A Salvador-Pascual… - Free radical biology and …, 2019 - Elsevier
Sarcopenia is a major component of the frailty syndrome, both being considered as strong
predictors of morbidity, disability, and death in older people. In this review, we explore the …

Sarcopenia: assessment of disease burden and strategies to improve outcomes

I Liguori, G Russo, L Aran, G Bulli, F Curcio… - … interventions in aging, 2018 - Taylor & Francis
Life expectancy is increasing worldwide, with a resultant increase in the elderly population.
Aging is characterized by the progressive loss of skeletal muscle mass and strength–a …

Interventions for treating sarcopenia: a systematic review and meta-analysis of randomized controlled studies

Y Yoshimura, H Wakabayashi, M Yamada… - Journal of the American …, 2017 - Elsevier
Background Much interest has been focused on interventions for treating sarcopenia;
however, the effects have gained little evidence. Objective To analyze the effectiveness of …

Association between sarcopenia and levels of growth hormone and insulin-like growth factor-1 in the elderly

A Bian, Y Ma, X Zhou, Y Guo, W Wang, Y Zhang… - BMC musculoskeletal …, 2020 - Springer
Background Age-related sarcopenia is a serious global health issue in elderly individuals
and for the community as it induces disability and significant economic burden. The purpose …

Circulating factors associated with sarcopenia during ageing and after intensive lifestyle intervention

C Li, K Yu, NG Shyh‐Chang, G Li… - Journal of cachexia …, 2019 - Wiley Online Library
Background Ageing, chronic diseases, prolonged inactivity, and inadequate nutrition pose a
severe threat to skeletal muscle health and function. To date, experimental evidence …

Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials

E Marzetti, R Calvani, M Cesari, TW Buford… - The international journal …, 2013 - Elsevier
Sarcopenia, the age-related loss of muscle mass and function, imposes a dramatic burden
on individuals and society. The development of preventive and therapeutic strategies …

sarcopenia in cirrhosis–aetiology, implications and potential therapeutic interventions

M Sinclair, PJ Gow, M Grossmann… - Alimentary …, 2016 - Wiley Online Library
Background Sarcopenia (loss of muscle mass) is common in cirrhosis and is associated with
poor outcomes. Current teaching recommends the use of protein supplementation and …

Biochemical markers of musculoskeletal health and aging to be assessed in clinical trials of drugs aiming at the treatment of sarcopenia: consensus paper from an …

A Ladang, C Beaudart, JY Reginster… - Calcified Tissue …, 2023 - Springer
In clinical trials, biochemical markers provide useful information on the drug's mode of
action, therapeutic response and side effect monitoring and can act as surrogate endpoints …