Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

S Alberti, AA Hyman - Nature reviews Molecular cell biology, 2021 - nature.com
Biomolecular condensates are membraneless intracellular assemblies that often form via
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …

Engineering synthetic biomolecular condensates

Y Dai, L You, A Chilkoti - Nature Reviews Bioengineering, 2023 - nature.com
The concept of phase-separation-mediated formation of biomolecular condensates provides
a new framework to understand cellular organization and cooperativity-dependent cellular …

[HTML][HTML] Interface of biomolecular condensates modulates redox reactions

Y Dai, CF Chamberlayne, MS Messina, CJ Chang… - Chem, 2023 - cell.com
Biomolecular condensates mediate diverse cellular processes. The density-transition
process of condensate formation results in the selective partitioning of molecules, which …

[HTML][HTML] Multimaterial 3D printing of self-assembling smart thermo-responsive polymers into 4D printed objects: A review

M Shahbazi, H Jäger, R Ettelaie, A Mohammadi… - Additive …, 2023 - Elsevier
Abstract The three-dimensional (3D) printing and its extension four-dimensional (4D)
printing technique show great promise for advanced additive manufacturing of functional …

Hydrogel scaffolds for tissue engineering: the importance of polymer choice

CD Spicer - Polymer Chemistry, 2020 - pubs.rsc.org
Hydrogel scaffolds that can repair or regrow damaged biological tissue have great potential
for the treatment of injury and disease. These biomaterials are widely used in the tissue …

Probing and engineering liquid-phase organelles

D Bracha, MT Walls, CP Brangwynne - Nature biotechnology, 2019 - nature.com
Cells compartmentalize their intracellular environment to orchestrate countless
simultaneous biochemical processes. Many intracellular tasks rely on membrane-less …

Intrinsically disordered protein regions and phase separation: sequence determinants of assembly or lack thereof.

EW Martin, AS Holehouse - Emerging topics in life sciences, 2020 - europepmc.org
Intrinsically disordered protein regions (IDRs)-regions that do not fold into a fixed three-
dimensional structure but instead exist in a heterogeneous ensemble of conformations-have …

Biomolecular condensates formed by designer minimalistic peptides

A Baruch Leshem, S Sloan-Dennison… - Nature …, 2023 - nature.com
Inspired by the role of intracellular liquid-liquid phase separation (LLPS) in formation of
membraneless organelles, there is great interest in develo** dynamic compartments …

Fluid protein condensates for bio-inspired applications

MJ Harrington, R Mezzenga, A Miserez - Nature Reviews …, 2024 - nature.com
Since the discovery of tropoelastin liquid–liquid phase separation in the 1950s, it has been
recognized that fluid protein condensates, including coacervates and liquid crystals, are …

Programming molecular self-assembly of intrinsically disordered proteins containing sequences of low complexity

JR Simon, NJ Carroll, M Rubinstein, A Chilkoti… - Nature …, 2017 - nature.com
Dynamic protein-rich intracellular structures that contain phase-separated intrinsically
disordered proteins (IDPs) composed of sequences of low complexity (SLC) have been …