Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

Phenotypes are rarely consistent across genetic backgrounds and environments, but
instead vary in many ways depending on allelic variants, unlinked genes, epigenetic factors …

Background Diagnostics of the human ageing process may help predict future healthcare
needs or guide preventative measures for tackling diseases of older age. We take a …

Extreme longevity is the paradigm of healthy aging as individuals who reached the extreme
decades of human life avoided or largely postponed all major age-related diseases. In this …

We developed a new statistical framework to find genetic variants associated with extreme
longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large …

Human longevity is a complex trait, and to disentangle its basis has a great theoretical and
practical consequences for biomedicine. The genetics of human longevity is still poorly …

Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …

Background Since glycosylation depends on glycosyltransferases, glycosidases, and sugar
nucleotide donors, it is susceptible to the changes associated with physiological and …

The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …

Caloric restriction (CR), defined as decreased nutrient intake without causing malnutrition,
has been documented to increase both health and lifespan across numerous organisms …