Excessive adiposity raises blood pressure and accounts for 65–75% of primary
hypertension, which is a major driver of cardiovascular and kidney diseases. In obesity …

Excess weight gain, especially when associated with increased visceral adiposity, is a major
cause of hypertension, accounting for 65% to 75% of the risk for human primary (essential) …

Abstract Obesity contributes 65–75% of the risk for human primary (essential) hypertension
(HT) which is a major driver of cardiovascular and kidney diseases. Kidney dysfunction …

Renal sympathetic (efferent) nerves play an important role in the regulation of renal function,
including glomerular filtration, sodium reabsorption, and renin release. The kidney is also …

The metabolic syndrome (MetS) is a cluster of clinical disorders including an unhealthy body
habitus with a large waistline, dyslipidemia, glucose intolerance and hypertension. It is …

The issue of whether angiotensin II infusion increases renal sympathetic nerve activity was
clarified in studies in conscious rabbits consuming a high NaCl diet. 4 Using a low dose of …

The sympathetic nervous system plays a pivotal role in the long-term regulation of arterial
blood pressure through the ability of the central nervous system to integrate neurohumoral …

Over the past several decades, studies of the sympathetic nervous system in humans,
sheep, rabbits, rats, and mice have substantially increased mechanistic understanding of …

The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including insulin
resistance (IR), dyslipidemia, and hypertension, which may also foster development of …

In addition to effects on appetite and metabolism, leptin influences many neuroendocrine
and physiological systems, including the sympathetic nervous system. Building on my Carl …