Sirtuins (SIRT), first discovered in yeast as NAD+ dependent epigenetic and metabolic
regulators, have comparable activities in human physiology and disease. Mounting …

SIRT1 protein, a member of Silent Information Regulator 2 (Sir2) protein family, have gained
considerable attention as epigenetic regulators for a great area in the human physiology …

Abstract Sirtuin 1 (SIRT1) is a prototype mammalian NAD (+)-dependent protein deacetylase
that has emerged as a key metabolic sensor in various metabolic tissues. Growing evidence …

Single cell RNA sequencing studies identified novel neurodegeneration-associated
microglial (MGnD/DAM) subtypes activated around cerebral amyloid plaques. Micro-RNA …

As the applications and environmental release of silver ions and nanoparticles are
increasing, increasing human exposure to these pollutants has become an emerging health …

Trypanosoma cruzi is a digenetic parasite that requires triatomines and mammalian host to
complete its life cycle. T. cruzi replication in mammalian host induces immune-mediated …

Abstract 20 years ago, we described a human cell strain derived from subcutaneous
adipose tissue of an infant supposed to have Simpson-Golabi-Behmel Syndrome (SGBS) …

Ulcerative colitis (UC) is a common chronic, idiopathic inflammatory bowel disease
associated with inflammatory perturbation and oxidative stress. Umbelliferone (UMB) is a …

Obesity, a complex disease involving an excessive amount of body fat and a major threat to
public health all over the world, is the determining factor of the onset and development of …

Adipose tissue is instrumental in maintaining metabolic homeostasis by regulating energy
storage in the form of triglycerides. In the case of over-nutrition, adipocytes favorably …