A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

The discovery of the Sry gene in 1990 triggered a revolution in our understanding of sex
determination. More recently, advances in non-model organisms have been fuelled by the …

The dmrt1 (doublesex and mab-3 related transcription factor 1) gene is a key regulator of
sex determination and/or gonadal sex differentiation across metazoan animals. This is …

Zebrafish are an established research organism that has made many contributions to our
understanding of vertebrate tissue and organ development, yet there are still significant …

To date, more than 20 different vertebrate master sex-determining genes have been
identified on different sex chromosomes of mammals, birds, frogs and fish. Interestingly, six …

It is well accepted that Forkhead box protein L2 (Foxl2) and aromatase (Cyp19a1; the
enzyme responsible for estrogen synthesis) are critical for ovarian development in …

Sex is determined by multiple factors derived from somatic and germ cells in vertebrates. We
have identified amhy, dmrt1, gsdf as male and foxl2, foxl3, cyp19a1a as female sex …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

Spermatogenesis is a fundamental process in male reproductive biology and depends on
precise balance between self-renewal and differentiation of male germ cells. However, the …

Over the last several decades zebrafish (Danio rerio) has become a major model organism
for the study of vertebrate development and physiology. Given this, it may be surprising how …