G-protein-coupled receptors (GPCRs) transduce physiological and sensory stimuli into
appropriate cellular responses and mediate the actions of one-third of drugs. GPCR …

Background: Cannabinoid has long been used for medicinal purposes. Cannabinoid
signaling has been considered the therapeutic target for treating pain, addiction, obesity …

The μ-opioid receptor (μOR) is a G-protein-coupled receptor (GPCR) and the target of most
clinically and recreationally used opioids. The induced positive effects of analgesia and …

Heterotrimetic G proteins consist of four subfamilies (G s, G i/o, G q/11, and G 12/13) that
mediate signaling via G-protein-coupled receptors (GPCRs), principally by receptors binding …

Summary Serotonin (or 5-hydroxytryptamine, 5-HT) is an important neurotransmitter that
activates 12 different G protein-coupled receptors (GPCRs) through selective coupling of G …

G-protein-coupled receptors (GPCRs) form the largest family of receptors encoded by the
human genome (around 800 genes). They transduce signals by coupling to a small number …

Abstract Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that maintains
circadian rhythms by synchronization to environmental cues and is involved in diverse …

Adhesion G protein-coupled receptors (aGPCRs)—one of the five main families in the GPCR
superfamily—have several atypical characteristics, including large, multi-domain N termini …

G-protein-coupled receptors (GPCRs) are the largest and most diverse group of membrane
receptors in eukaryotes and detect a wide array of cues in the human body. Here we …

Membrane receptors sense and transduce extracellular stimuli into intracellular signaling
responses but the molecular underpinnings remain poorly understood. We report a …