Abstract Growth differentiation factor 15 (GDF15) is recently emerging not only as a stress-
related mitokine, but also as a key player in the aging process, being one of the most up …

Empirical evidence for declines in fitness components (survival and reproductive
performance) with age has recently accumulated in wild populations, highlighting that the …

ABSTRACT A common, long‐held belief is that metabolic rate drives the rates of various
biological, ecological and evolutionary processes. Although this metabolic pacemaker view …

Many studies in humans have shown that adverse experience in early life is associated with
accelerated reproductive timing, and there is comparative evidence for similar effects in …

Physiologists often assume that mitochondria are the main producers of reactive oxygen
species (ROS) in cells. Consequently, in biomedicine, mitochondria are considered as …

According to recent empirical studies, reproductive senescence, the decline in reproductive
success with increasing age, seems to be nearly ubiquitous in the wild. However, a clear …

At present, there may be over 210,000 people with Down syndrome (DS) over the age of 55
in the United States (US) who have significant needs for augmented services due to …

Development consists of a highly ordered suite of steps and transitions, like choreography.
Although these sequences are often evolutionarily conserved, they can display species …

Bats live longer than similar-sized mammals, but the number of lineages that have
independently evolved extreme longevity has not previously been determined. Here we …

Evolutionary biology and biomedicine have seen a surge of recent interest in the possibility
that telomeres play a role in life-history trade-offs and ageing. Here, I evaluate alternative …