This work discusses bioinformatics and experimental approaches to explore the human
proteome, a constellation of proteins expressed in different tissues and organs. As the …

The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

The fundamental mission of the Chromosome-Centric Human Proteome Project (C-HPP) is
the research of human proteome diversity, including rare variants. Liver tissues, HepG2 …

The ancient Greeks attributed life to Mother Nature, complaining that she was fond of hiding
the workings of her creations. Although we no longer attribute the mysteries of life to Mother …

Abstract Background Human hepatoma HepG2 cells are used as an in vitro model of the
human liver. High-throughput transcriptomic sequencing is an advanced approach for …

Hard conditions of long-term manned spaceflight can affect functions of many biological
systems including a system of drug metabolism. The cytochrome P450 (CYP) superfamily …

This work was aimed at estimating the concentrations of proteins encoded by human
chromosome 18 (Chr 18) in plasma samples of 54 healthy male volunteers (aged 20–47) …

This work continues the series of the quantitative measurements of the proteins encoded by
different chromosomes in the blood plasma of a healthy person. Selected Reaction …

Introduction: Multiple (or selected) reaction monitoring-mass spectrometry (MRM/SRM) is a
targeted proteomic method that can be used for relative and absolute quantification. Multiple …

In this work targeted (selected reaction monitoring, SRM, PASSEL: PASS00697) and
panoramic (shotgun LC–MS/MS, PRIDE: PXD00244) mass-spectrometric methods as well …