Atopic dermatitis: an expanding therapeutic pipeline for a complex disease

T Bieber - Nature reviews Drug discovery, 2022 - nature.com
Atopic dermatitis (AD) is a common chronic inflammatory skin disease with a complex
pathophysiology that underlies a wide spectrum of clinical phenotypes. AD remains …

Current and future status of JAK inhibitors

DP McLornan, JE Pope, J Gotlib, CN Harrison - The lancet, 2021 - thelancet.com
An enhanced understanding of the importance of Janus kinase (JAK) and signal transducer
and activator of transcription (STAT) signalling in multiple disease states has led to an …

European guideline (EuroGuiDerm) on atopic eczema: part I–systemic therapy

A Wollenberg, M Kinberger, B Arents… - Journal of the …, 2022 - Wiley Online Library
The evidence‐and consensus‐based guideline on atopic eczema was developed in
accordance with the EuroGuiDerm Guideline and Consensus Statement Development …

Efficacy and safety of upadacitinib vs dupilumab in adults with moderate-to-severe atopic dermatitis: a randomized clinical trial

A Blauvelt, HD Teixeira, EL Simpson… - JAMA …, 2021 - jamanetwork.com
Importance Atopic dermatitis (AD) is a chronic, recurrent, inflammatory skin disease with an
unmet need for treatments that provide rapid and high levels of skin clearance and itch …

European guideline (EuroGuiDerm) on atopic eczema–part II: non‐systemic treatments and treatment recommendations for special AE patient populations

A Wollenberg, M Kinberger, B Arents… - Journal of the …, 2022 - Wiley Online Library
The evidence‐and consensus‐based guideline on atopic eczema was developed in
accordance with the EuroGuiDerm Guideline and Consensus Statement Development …

JAK inhibitors in the treatment of atopic dermatitis

R Chovatiya, AS Paller - Journal of Allergy and Clinical Immunology, 2021 - Elsevier
Atopic dermatitis (AD) is a chronic inflammatory skin disorder associated with heterogenous
presentation and often immense patient burden. Safe, targeted treatment options are …

Abrocitinib versus placebo or dupilumab for atopic dermatitis

T Bieber, EL Simpson, JI Silverberg… - … England Journal of …, 2021 - Mass Medical Soc
Abstract Background The oral Janus kinase 1 (JAK1) inhibitor abrocitinib, which reduces
interleukin-4 and interleukin-13 signaling, is being investigated for the treatment of atopic …

JAK–STAT signaling pathway in the pathogenesis of atopic dermatitis: An updated review

IH Huang, WH Chung, PC Wu, CB Chen - Frontiers in immunology, 2022 - frontiersin.org
Atopic dermatitis (AD) is a chronic, inflammatory, pruritic form of dermatosis with
heterogeneous manifestations that can substantially affect patients' quality of life. AD has a …

Update on the pathogenesis and therapy of atopic dermatitis

H Li, Z Zhang, H Zhang, Y Guo, Z Yao - Clinical reviews in allergy & …, 2021 - Springer
Atopic dermatitis (AD) is a common inflammatory skin disorder characterized by recurrent
eczematous lesions and intense itch. Although it most often starts in infancy and affects …

A review on the safety of using JAK inhibitors in dermatology: clinical and laboratory monitoring

C Samuel, H Cornman, A Kambala… - Dermatology and Therapy, 2023 - Springer
Janus kinase (JAK) inhibitors are disease-modifying agents with efficacy in treating a
spectrum of burdensome dermatologic conditions. The US Food and Drug Administration …