Development of potential cathepsin B inhibitors: Synthesis of new bithiazole derivatives, in vitro studies supported with theoretical docking studies
S Yadav, C Vashisth, V Chaudhri, K Singh… - International Journal of …, 2024 - Elsevier
Cysteine cathepsins play a crucial role in cancer, inflammation, and the regulation of
degenerative processes such as apoptosis, making them significant targets in drug …
degenerative processes such as apoptosis, making them significant targets in drug …
Antiproliferative activity in metastatic breast cancer cells of nanoparticles containing a novel indole-thiazole derivative
Indole and thiazole derivatives have been key players in the development of new drugs for
the treatment of cancer. However, physicochemical limitations may be a problem for the use …
the treatment of cancer. However, physicochemical limitations may be a problem for the use …
2-(4-Nitrophenyl) isothiazol-3 (2H)-one: A Promising Selective Agent against Hepatocellular Carcinoma Cells
S Marka, ME Zografaki, G Tsolomiti, KI Kalliampakou… - Pharmaceuticals, 2024 - mdpi.com
Liver cancer ranks among the most prevalent malignancies globally and stands as a leading
cause of cancer-related mortality. Numerous isothiazolone derivatives and analogues have …
cause of cancer-related mortality. Numerous isothiazolone derivatives and analogues have …
[HTML][HTML] Synthesis and Biological Evaluation of Novel Furopyridone Derivatives as Potent Cytotoxic Agents against Esophageal Cancer
X Ren, J Zhang, A Dai, P Sun, Y Zhang, L **… - International Journal of …, 2024 - mdpi.com
Cancer continues to be a major global health issue, ranking among the top causes of death
worldwide. To develop novel antitumor agents, this study focused on the synthesis of a …
worldwide. To develop novel antitumor agents, this study focused on the synthesis of a …
Synthesis, characterization and anticancer investigation of some novel 2, 5-disubstituted-1, 3-thiazol-4-(5H)-ones and 1-substituted-1H-pyrazolo [3, 4-d] thiazole …
Abstract Fused pyrazoles and 2, 5-disubstituted thiazolinone derivatives are attractive
molecules for drug design development that are widely recognized as significant biological …
molecules for drug design development that are widely recognized as significant biological …
Structure‐Activity Relationship of Hydrazinylthiazole‐5‐Carbaldehydes as Potential Anti‐Diabetic Agents
S Siddique choudhry, H Mehmood… - Chemistry & …, 2024 - Wiley Online Library
Diabetes is an emerging threat to the world due to large number of deaths reported within
the last decade. To overcome its spread and complications, herein, we reported synthesis …
the last decade. To overcome its spread and complications, herein, we reported synthesis …