Mechanisms underlying the protective effects of mesenchymal stem cell-based therapy

XL Fan, Y Zhang, X Li, QL Fu - Cellular and molecular life sciences, 2020 - Springer
Mesenchymal stem cells (MSCs) have been extensively investigated for the treatment of
various diseases. The therapeutic potential of MSCs is attributed to complex cellular and …

Biomaterials functionalized with MSC secreted extracellular vesicles and soluble factors for tissue regeneration

MÁ Brennan, P Layrolle… - Advanced functional …, 2020 - Wiley Online Library
The therapeutic benefits of mesenchymal stromal cell (MSC) transplantation are attributed to
their secreted factors, including extracellular vesicles (EVs) and soluble factors. The …

Regenerative capacity of adipose derived stem cells (ADSCs), comparison with mesenchymal stem cells (MSCs)

L Mazini, L Rochette, M Amine, G Malka - International journal of …, 2019 - mdpi.com
Adipose tissue is now on the top one of stem cell sources regarding its accessibility,
abundance, and less painful collection procedure when compared to other sources. The …

Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress

X Wu, J Jiang, Z Gu, J Zhang, Y Chen, X Liu - Stem cell research & …, 2020 - Springer
Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic
fibroblast-like cells that can differentiate into cells of multiple lineages, such as …

Multiple sclerosis: pathogenesis, symptoms, diagnoses and cell-based therapy

N Ghasemi, S Razavi, E Nikzad - Cell Journal (Yakhteh), 2016 - pmc.ncbi.nlm.nih.gov
Multiple sclerosis (MS) is a chronic inflammatory disease characterized by central nervous
system (CNS) lesions that can lead to severe physical or cognitive disability as well as …

[HTML][HTML] Adipose-derived stem cells secretome and its potential application in “stem cell-free therapy”

A Trzyna, A Banaś-Ząbczyk - Biomolecules, 2021 - mdpi.com
Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and
extracellular vesicles with beneficial outcomes that can be used in regenerative medicine. It …

[HTML][HTML] Platelets facilitate the wound-healing capability of mesenchymal stem cells by mitochondrial transfer and metabolic reprogramming

J Levoux, A Prola, P Lafuste, M Gervais, N Chevallier… - Cell metabolism, 2021 - cell.com
Platelets are known to enhance the wound-healing activity of mesenchymal stem cells
(MSCs). However, the mechanism by which platelets improve the therapeutic potential of …

Treatment of spinal cord injury with mesenchymal stem cells

LL Liau, QH Looi, WC Chia, T Subramaniam, MH Ng… - Cell & bioscience, 2020 - Springer
Background Spinal cord injury (SCI) is the damage to the spinal cord that can lead to
temporary or permanent loss of function due to injury to the nerve. The SCI patients are often …

Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling

L Wang, L Hu, X Zhou, Z **ong, C Zhang… - Scientific Reports, 2017 - nature.com
Scar formation is an intractable medical problem that appears after skin wounds have
healed. Recent research has shown that exosomes secreted by human adipose …

Paracrine mechanisms of mesenchymal stem cells in tissue repair

M Gnecchi, P Danieli, G Malpasso… - Mesenchymal Stem Cells …, 2016 - Springer
Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …