Biased signalling: from simple switches to allosteric microprocessors
G protein-coupled receptors (GPCRs) are the largest class of receptors in the human
genome and some of the most common drug targets. It is now well established that GPCRs …
genome and some of the most common drug targets. It is now well established that GPCRs …
Stress-induced reinstatement of drug seeking: 20 years of progress
In human addicts, drug relapse and craving are often provoked by stress. Since 1995, this
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
clinical scenario has been studied using a rat model of stress-induced reinstatement of drug …
The association between mobile game addiction and depression, social anxiety, and loneliness
JL Wang, JR Sheng, HZ Wang - Frontiers in public health, 2019 - frontiersin.org
As a new type of addictive behaviors and distinct from traditional internet game addiction on
desktop computers, mobile game addiction has attracted researchers' attention due to its …
desktop computers, mobile game addiction has attracted researchers' attention due to its …
Bioresorbable silicon electronic sensors for the brain
Many procedures in modern clinical medicine rely on the use of electronic implants in
treating conditions that range from acute coronary events to traumatic injury,. However …
treating conditions that range from acute coronary events to traumatic injury,. However …
Injectable, cellular-scale optoelectronics with applications for wireless optogenetics
Successful integration of advanced semiconductor devices with biological systems will
accelerate basic scientific discoveries and their translation into clinical technologies. In …
accelerate basic scientific discoveries and their translation into clinical technologies. In …
Molecular mechanisms of opioid receptor-dependent signaling and behavior
Opioid receptors have been targeted for the treatment of pain and related disorders for
thousands of years, and remain the most widely used analgesics in the clinic. Mu (μ), kappa …
thousands of years, and remain the most widely used analgesics in the clinic. Mu (μ), kappa …
Video game addiction in emerging adulthood: Cross-sectional evidence of pathology in video game addicts as compared to matched healthy controls
Abstract Background The Internet Gaming Disorder Scale (IGDS) is a widely used measure
of video game addiction, a pathology affecting a small percentage of all people who play …
of video game addiction, a pathology affecting a small percentage of all people who play …
A motivational and neuropeptidergic hub: anatomical and functional diversity within the nucleus accumbens shell
The mesocorticolimbic pathway is canonically known as the" reward pathway." Embedded
within the center of this circuit is the striatum, a massive and complex network hub that …
within the center of this circuit is the striatum, a massive and complex network hub that …
Distinct subpopulations of nucleus accumbens dynorphin neurons drive aversion and reward
The nucleus accumbens (NAc) and the dynorphinergic system are widely implicated in
motivated behaviors. Prior studies have shown that activation of the dynorphin-kappa opioid …
motivated behaviors. Prior studies have shown that activation of the dynorphin-kappa opioid …
Nociceptin/orphanin FQ receptor structure, signaling, ligands, functions, and interactions with opioid systems
The NOP receptor (nociceptin/orphanin FQ opioid peptide receptor) is the most recently
discovered member of the opioid receptor family and, together with its endogenous ligand …
discovered member of the opioid receptor family and, together with its endogenous ligand …