Scarring is part of the normal healing response to tissue injury in all organs and required to
rapidly repair acute damages, mostly with extracellular matrix. A variety of different cells are …

Non-healing, chronic wounds place a huge burden on healthcare systems as well as
individual patients. These chronic wounds especially diabetic wounds will ultimately lead to …

The infrapatellar fat pad (IPFP) and synovium play essential roles in maintaining knee joint
homeostasis and in the progression of osteoarthritis (OA). The cellular and transcriptional …

The regeneration of bone tissue is regulated by both osteogenic and angiogenic growth
factors which are expressed in a coordinated cascade of events. The aim of this study was to …

Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or
damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction …

Myofibroblasts, and the extracellular matrix (ECM) in which they reside, are critical
components of wound healing and fibrosis. The ECM, traditionally viewed as the structural …

It is estimated worldwide that over 6 million people per annum experience a burn injury.
Despite advances in management and improved survival rates, the incidence of …

Fibrosis is responsible for chronic progressive kidney failure, which is present in a large
number of adults in the developed world. It is increasingly appreciated that acute kidney …

CTGF is a secreted matricellular protein with very complex biology. It has been shown to
modulate many signaling pathways leading to cell adhesion and migration, angiogenesis …

Cellular senescence is a recognized mechanism of tumour suppression; however, its
contribution to other pathologies is not well understood. We show that the matricellular …