Proper muscle function constitutes a precondition for good heath and an active lifestyle
during an individual's lifespan and any deviations from normal skeletal muscle development …

Multi-pathway approaches for the treatment of complex polygenic disorders are emerging as
alternatives to classical monotarget therapies and microRNAs are of particular interest in …

Replacing or editing disease-causing mutations holds great promise for treating many
human diseases. Yet, delivering therapeutic genetic modifiers to specific cells in vivo has …

Administration of human cord blood endothelial colony-forming cells (ECFCs) or their
exosomes protects mice against kidney ischemia/reperfusion injury. Here we studied the …

Background Myocardial ischemia–reperfusion injury (MIRI) is a major obstacle in the
treatment of ischemic heart disease. Recent studies have shown that exosomes—small …

Purpose Childhood obesity increases susceptibility to type 2 diabetes (T2D) in adults.
Circulating microRNAs (miRNAs) in serum have been proposed as potential diagnostic …

Summary microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly
downregulated microRNAs (miRNAs) in the brain of Alzheimer's disease (AD) patients …

Abstract Background Small RNAs present in bovine ejaculate can be linked to sperm
abnormalities and fertility disorders. At present, quality parameters routinely used in semen …

A growing body of evidence indicates that cardiac regeneration after myocardial infarction
can be achieved by stimulating the endogenous capacity of cardiomyocytes (CMs) to …

Plasma circulating extracellular vesicles (EVs) have been utilized as a potential therapeutic
strategy to treat ischemic disease through intramyocardial injection (efficient but invasive) or …