Metabolic disorders have become among the most serious threats to human health, leading
to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver …

Calmodulin (CaM) is a ubiquitous Ca 2+ receptor protein mediating a large number of
signaling processes in all eukaryotic cells. CaM plays a central role in regulating a myriad of …

Ca2+ is essential for virus entry, viral gene replication, virion maturation, and release. The
alteration of host cells Ca2+ homeostasis is one of the strategies that viruses use to …

The calcium pump (aka Ca 2+-ATPase or SERCA) is a membrane transport protein
ubiquitously found in the endoplasmic reticulum (ER) of all eukaryotic cells. As a calcium …

Skeletal muscle constitutes∼ 40% of body mass and has the capacity to play a major role as
thermogenic, metabolic, and endocrine organ. In addition to shivering, muscle also …

Abstract Plasma membrane Ca2+-ATPases (PMCAs) are key regulators of global Ca2+
homeostasis and local intracellular Ca2+ dynamics. Recently, Neuroplastin (NPTN) and …

Platelet activation triggers thrombus formation in physiological and pathological conditions,
such as acute coronary syndromes. Current therapies still fail to prevent thrombotic events in …

The human epidermis provides a very effective barrier function against chemical, physical
and microbial insults from the environment. This is only possible as the epidermis renews …

The neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease
(PD), Amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and Spinocerebellar …

In the last few decades, a large body of experimental evidence has highlighted the complex
role for mitochondria in eukaryotic cells: they are not only the site of aerobic metabolism …