The somatic mutations in each cancer genome are caused by multiple mutational
processes, each of which leaves a characteristic imprint (or 'signature'), potentially caused …

Abstract The Catalogue Of Somatic Mutations In Cancer (COSMIC), https://cancer. sanger.
ac. uk/cosmic, is an expert-curated knowledgebase providing data on somatic variants in …

Whole-genome sequencing (WGS) permits comprehensive cancer genome analyses,
revealing mutational signatures, imprints of DNA damage, and repair processes that have …

Colorectal carcinoma (CRC) is a common cause of mortality, but a comprehensive
description of its genomic landscape is lacking,,,,,,–. Here we perform whole-genome …

Gains and losses of DNA are prevalent in cancer and emerge as a consequence of inter-
related processes of replication stress, mitotic errors, spindle multipolarity and breakage …

The evolutionary processes that underlie the marked sensitivity of small cell lung cancer
(SCLC) to chemotherapy and rapid relapse are unknown,–. Here we determined tumour …

Pancreatic intraepithelial neoplasias (PanINs) are the most common precursors of
pancreatic cancer, but their small size and inaccessibility in humans make them challenging …

Recent studies have documented frequent evolution of clones carrying common cancer
mutations in apparently normal tissues, which are implicated in cancer development …

Clustered somatic mutations are common in cancer genomes and previous analyses reveal
several types of clustered single-base substitutions, which include doublet-and multi-base …

Motivation Analysis of mutational signatures is a powerful approach for understanding the
mutagenic processes that have shaped the evolution of a cancer genome. To evaluate the …