Rho GTPases are well known to regulate actin dynamics. They activate two types of actin
nucleators, WASP/WAVE proteins and Diaphanous-related formins (DRFs), which induce …

Neurons can sustain high rates of synaptic transmission without exhausting their supply of
synaptic vesicles. This property relies on a highly efficient local endocytic recycling of …

Guanine nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins
(RhoGAPs) coordinate the activation state of the Rho family of GTPases for binding to …

The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from
yeast to human and is also found in endophilins and nadrins. We solved the structure of the …

The dynamic remolding of the actin cytoskeleton is a critical part of most cellular activities,
and malfunction of cytoskeletal proteins results in various human diseases. The transition …

Endocytosis includes a number of processes by which cells internalize segments of their
plasma membrane, enclosing a wide variety of material from outside the cell. Endocytosis …

Actin filament assembly typically occurs in association with cellular membranes. A large
number of proteins sit at the interface between actin networks and membranes, playing …

Cell membranes undergo continuous curvature changes as a result of membrane trafficking
and cell motility. Deformations are achieved both by forces extrinsic to the membrane as well …

Background & Aims Tumor necrosis factor (TNF) increases intestinal epithelial cell shedding
and apoptosis, potentially challenging the barrier between the gastrointestinal lumen and …

Dynamin, which is encoded by three genes in mammals, is a GTPase implicated in
endocytic membrane fission. Dynamin 1 and 3 are predominantly expressed in brain …