Flavonoids as an effective sensitizer for anti-cancer therapy: Insights into multi-faceted mechanisms and applicability towards individualized patient profiles

A Liskova, M Samec, L Koklesova, A Brockmueller… - Epma Journal, 2021 - Springer
Cost-efficacy of currently applied treatments is an issue in overall cancer management
challenging healthcare and causing tremendous economic burden to societies around the …

Flavonoids against non-physiologic inflammation attributed to cancer initiation, development, and progression—3PM pathways

P Kubatka, A Mazurakova, M Samec, L Koklesova… - Epma Journal, 2021 - Springer
Inflammation is an essential pillar of the immune defense. On the other hand, chronic
inflammation is considered a hallmark of cancer initiation and progression. Chronic …

Caution,“normal” BMI: health risks associated with potentially masked individual underweight—EPMA Position Paper 2021

O Golubnitschaja, A Liskova, L Koklesova, M Samec… - EPMA Journal, 2021 - Springer
An increasing interest in a healthy lifestyle raises questions about optimal body weight.
Evidently, it should be clearly discriminated between the standardised “normal” body weight …

All around suboptimal health—a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and …

W Wang, Y Yan, Z Guo, H Hou, M Garcia, X Tan… - EPMA Journal, 2021 - Springer
First two decades of the twenty-first century are characterised by epidemics of non-
communicable diseases such as many hundreds of millions of patients diagnosed with …

Mitochondrial impairments in aetiopathology of multifactorial diseases: common origin but individual outcomes in context of 3P medicine

L Koklesova, M Samec, A Liskova, K Zhai… - EPMA Journal, 2021 - Springer
Mitochondrial injury plays a key role in the aetiopathology of multifactorial diseases
exhibiting a “vicious circle” characteristic for pathomechanisms of the mitochondrial and …

Prostate cancer treatment costs increase more rapidly than for any other cancer—how to reverse the trend?

J Ellinger, A Alajati, P Kubatka, FA Giordano, M Ritter… - EPMA Journal, 2022 - Springer
Abstract According to GLOBOCAN, about 1.41 million new prostate cancer (PCa) cases
were registered in the year 2020 globally. The corresponding socio-economic burden is …

Central nervous system metastases from triple-negative breast cancer: current treatments and future prospective

A Kadamkulam Syriac, NS Nandu… - Breast Cancer: Targets …, 2023 - Taylor & Francis
It is estimated that approximately one-third of patients with triple-negative breast cancer
(TNBC) will develop brain metastases. The prognosis for patients with breast cancer brain …

Sleep quality and COVID-19 outcomes: the evidence-based lessons in the framework of predictive, preventive and personalised (3P) medicine

K Richter, S Kellner, T Hillemacher, O Golubnitschaja - EPMA Journal, 2021 - Springer
Sleep quality and duration play a pivotal role in maintaining physical and mental health. In
turn, sleep shortage, deprivation and disorders are per evidence the risk factors and …

ctDNA-based liquid biopsy of cerebrospinal fluid in brain cancer

L Escudero, F Martínez-Ricarte, J Seoane - Cancers, 2021 - mdpi.com
Simple Summary The optimal treatment and management of patients with brain cancer
depend on the molecular characteristics of their tumour. Since the tumour changes with time …

A practical guide to chimerism analysis: review of the literature and testing practices worldwide

AG Blouin, F Ye, J Williams, M Askar - Human immunology, 2021 - Elsevier
Abstract Background and Purpose Currently there are no widely accepted guidelines for
chimerism analysis testing in hematopoietic cell transplantation (HCT) patients. The …