Uric acid and hypertension: a review of evidence and future perspectives for the management of cardiovascular risk

C Borghi, D Agnoletti, AFG Cicero, E Lurbe… - Hypertension, 2022 - Am Heart Assoc
Uric acid is the final product of purine metabolism, and its increased serum levels have been
directly involved in the pathogenesis and natural history of hypertension. The relationship …

Chronic kidney disease of unknown cause in agricultural communities

RJ Johnson, C Wesseling… - New England Journal of …, 2019 - Mass Medical Soc
Chronic Kidney Disease in Agricultural Communities Numerous cases of chronic kidney
disease of unknown cause have emerged among agricultural workers and other manual …

Climate change and the emergent epidemic of CKD from heat stress in rural communities: the case for heat stress nephropathy

J Glaser, J Lemery, B Rajagopalan… - Clinical Journal of the …, 2016 - journals.lww.com
Climate change has led to significant rise of 0.8 C–0.9 C in global mean temperature over
the last century and has been linked with significant increases in the frequency and severity …

[HTML][HTML] Heat stress, dehydration, and kidney function in sugarcane cutters in El Salvador–a cross-shift study of workers at risk of Mesoamerican nephropathy

R García-Trabanino, E Jarquín, C Wesseling… - Environmental …, 2015 - Elsevier
Background An epidemic of progressive kidney failure afflicts sugarcane workers in Central
America. Repeated high-intensity work in hot environments is a possible cause. Objectives …

[HTML][HTML] Fructose contributes to the Warburg effect for cancer growth

T Nakagawa, MA Lanaspa, IS Millan, M Fini… - Cancer & …, 2020 - Springer
Obesity and metabolic syndrome are strongly associated with cancer, and these disorders
may share a common mechanism. Recently, fructose has emerged as a driving force to …

Uric acid and hypertension: an update with recommendations

LG Sanchez-Lozada, B Rodriguez-Iturbe… - American journal of …, 2020 - academic.oup.com
The association between increased serum urate and hypertension has been a subject of
intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones …

[HTML][HTML] Climate change and the kidney

RJ Johnson, LG Sánchez-Lozada… - Annals of Nutrition and …, 2019 - karger.com
The worldwide increase in temperature has resulted in a marked increase in heat waves
(heat extremes) that carries a markedly increased risk for morbidity and mortality. The kidney …

[HTML][HTML] Occupational heat stress and kidney health: from farms to factories

FB Nerbass, R Pecoits-Filho, WF Clark… - Kidney international …, 2017 - Elsevier
Millions of workers around the world are exposed to high temperatures, intense physical
activity, and lax labor practices that do not allow for sufficient rehydration breaks. The extent …

Global dimensions of chronic kidney disease of unknown etiology (CKDu): a modern era environmental and/or occupational nephropathy?

VM Weaver, JJ Fadrowski, BG Jaar - BMC nephrology, 2015 - Springer
Diabetes and hypertension are the predominant risk factors for chronic kidney disease
(CKD) globally. Infectious diseases resulting in glomerulonephritis are also important in low …

Chronic interstitial nephritis in agricultural communities: a worldwide epidemic with social, occupational and environmental determinants

C Jayasumana, C Orantes, R Herrera… - Nephrology Dialysis …, 2017 - academic.oup.com
Increase in the prevalence of chronic kidney disease (CKD) is observed in Central America,
Sri Lanka and other tropical countries. It is named chronic interstitial nephritis in agricultural …