Natural killer cell engagers (NKCEs): a new frontier in cancer immunotherapy

M Zhang, KP Lam, S Xu - Frontiers in Immunology, 2023 - frontiersin.org
Natural Killer (NK) cells are a type of innate lymphoid cells that play a crucial role in
immunity by killing virally infected or tumor cells and secreting cytokines and chemokines …

[HTML][HTML] Adaptive NK cell response to human cytomegalovirus: Facts and open issues

M López-Botet, A De Maria, A Muntasell… - Seminars in …, 2023 - Elsevier
Human cytomegalovirus (HCMV) infection exerts broad effects on the immune system.
These include the differentiation and persistent expansion of a mature NK cell subset which …

Perspectives of targeting LILRB1 in innate and adaptive immune checkpoint therapy of cancer

T Zeller, IA Münnich, R Windisch, P Hilger… - Frontiers in …, 2023 - frontiersin.org
Immune checkpoint blockade is a compelling approach in tumor immunotherapy. Blocking
inhibitory pathways in T cells has demonstrated clinical efficacy in different types of cancer …

Features of Memory-Like and PD-1+ Human NK Cell Subsets

M Della Chiesa, S Pesce, L Muccio… - Frontiers in …, 2016 - frontiersin.org
Human NK cells are distinguished into CD56brightCD16− cells and CD56dimCD16+ cells.
These two subsets are conventionally associated with differential functional outcomes and …

Activating NKG2C receptor: functional characteristics and current strategies in clinical applications

J Siemaszko, A Marzec-Przyszlak… - Archivum Immunologiae …, 2023 - Springer
The interest in NK cells and their cytotoxic activity against tumour, infected or transformed
cells continuously increases as they become a new efficient and off-the-shelf agents in …

Blood natural killer cell deficiency reveals an immunotherapy strategy for atopic dermatitis

MR Mack, JR Brestoff, MM Berrien-Elliott… - Science translational …, 2020 - science.org
Atopic dermatitis (AD) is a widespread, chronic skin disease associated with aberrant
allergic inflammation. Current treatments involve either broad or targeted …

CMV and natural killer cells: sha** the response to vaccination

MR Goodier, S Jonjić, EM Riley… - European journal of …, 2018 - Wiley Online Library
Cytomegaloviruses (CMVs) are highly prevalent, persistent human pathogens that not only
evade but also shape our immune responses. Natural killer (NK) cells play an important role …

Regulatory functions of natural killer cells in multiple sclerosis

CC Gross, A Schulte-Mecklenbeck, H Wiendl… - Frontiers in …, 2016 - frontiersin.org
There is increasing evidence that natural killer (NK) cells exhibit regulatory features. Among
them, CD56bright NK cells have been suggested to play a major role in controlling T cell …

Deciphering the killer‐cell immunoglobulin‐like receptor system at super‐resolution for natural killer and T‐cell biology

V Béziat, HG Hilton, PJ Norman, JA Traherne - Immunology, 2017 - Wiley Online Library
Killer‐cell immunoglobulin‐like receptors (KIR s) are components of two fundamental
biological systems essential for human health and survival. First, they contribute to host …

Impaired antibody-dependent cellular cytotoxicity in a Spanish cohort of patients with COVID-19 admitted to the ICU

L Vigon, J Garcia-Perez, S Rodriguez-Mora… - Frontiers in …, 2021 - frontiersin.org
SARS-CoV-2 infection causes COVID-19, ranging from mild to critical disease in
symptomatic subjects. It is essential to better understand the immunologic responses …