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Digital pathology and artificial intelligence
In modern clinical practice, digital pathology has a crucial role and is increasingly a
technological requirement in the scientific laboratory environment. The advent of whole-slide …
technological requirement in the scientific laboratory environment. The advent of whole-slide …
Mathematical modeling in cancer nanomedicine: a review
Cancer continues to be among the leading healthcare problems worldwide, and efforts
continue not just to find better drugs, but also better drug delivery methods. The need for …
continue not just to find better drugs, but also better drug delivery methods. The need for …
Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics
The progress of nanoparticle (NP)-based drug delivery has been hindered by an inability to
establish structure-activity relationships in vivo. Here, using stable, monosized, radiolabeled …
establish structure-activity relationships in vivo. Here, using stable, monosized, radiolabeled …
Conversion of RNA aptamer into modified DNA aptamers provides for prolonged stability and enhanced antitumor activity
Aptamers, synthetic single-strand oligonucleotides that are similar in function to antibodies,
are promising as therapeutics because of their minimal side effects. However, the stability …
are promising as therapeutics because of their minimal side effects. However, the stability …
[HTML][HTML] Histopathological images analysis and predictive modeling implemented in digital pathology—current affairs and perspectives
In modern clinical practice, digital pathology has an essential role, being a technological
necessity for the activity in the pathological anatomy laboratories. The development of …
necessity for the activity in the pathological anatomy laboratories. The development of …
Computerized segmentation and measurement of chronic wound images
An estimated 6.5 million patients in the United States are affected by chronic wounds, with
more than US $25 billion and countless hours spent annually for all aspects of chronic …
more than US $25 billion and countless hours spent annually for all aspects of chronic …
Mathematical prediction of clinical outcomes in advanced cancer patients treated with checkpoint inhibitor immunotherapy
We present a mechanistic mathematical model of immune checkpoint inhibitor therapy to
address the oncological need for early, broadly applicable readouts (biomarkers) of patient …
address the oncological need for early, broadly applicable readouts (biomarkers) of patient …
A mathematical model for the quantification of a patient's sensitivity to checkpoint inhibitors and long-term tumour burden
A large proportion of patients with cancer are unresponsive to treatment with immune
checkpoint blockade and other immunotherapies. Here, we report a mathematical model of …
checkpoint blockade and other immunotherapies. Here, we report a mathematical model of …
[HTML][HTML] Understanding the connection between nanoparticle uptake and cancer treatment efficacy using mathematical modeling
Nanoparticles have shown great promise in improving cancer treatment efficacy while
reducing toxicity and treatment side effects. Predicting the treatment outcome for …
reducing toxicity and treatment side effects. Predicting the treatment outcome for …
Integrated PK-PD and agent-based modeling in oncology
Mathematical modeling has become a valuable tool that strives to complement conventional
biomedical research modalities in order to predict experimental outcome, generate new …
biomedical research modalities in order to predict experimental outcome, generate new …